NDLI: Protein kinase A activity is required for the budding of constitutive transport vesicles from the trans-Golgi network.

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Protein kinase A activity is required for the budding of constitutive transport vesicles from the trans-Golgi network.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Muñiz, M. Hidalgo, J. Martín, M. E. Velasco, A.
Description	Author Affiliation: Muñiz M ( Department of Cell Biology, Faculty of Biology, University of Seville, 41012 Seville, Spain.);
Abstract	We have examined the role played by protein kinase A (PKA) in vesicle-mediated protein transport from the trans-Golgi network (TGN) to the cell surface. In vivo this transport step was inhibited by inhibitors of PKA catalytic subunits (C-PKA) such as the compound known as H89 and a myristoylated form of the inhibitory peptide sequence contained in the thermostable PKA inhibitor. Inhibition by H89 occurred at an early stage during the transfer of vesicular stomatitis virus G glycoprotein from the TGN to the cell surface. Reversal from this inhibition correlated with a transient increase in the number of free coated vesicles in the Golgi area. Vesicle budding from the TGN was studied in vitro using vesicular stomatitis virus-infected, permeabilized cells. Addition to this assay of C-PKA stimulated vesicle release while it was suppressed by PKA inhibitory peptide, H89, and antibody against C-PKA. Furthermore, vesicle release was decreased when PKA-depleted cytosol was used and restored by addition of C-PKA. These results indicate a regulatory role for PKA activity in the production of constitutive transport vesicles from the TGN.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cyclic AMP-Dependent Protein Kinases Physiology Cytoplasmic Granules Golgi Apparatus Ultrastructure Animals Biological Transport Cell Degranulation Cells, Cultured Microscopy, Electron Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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