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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Asano, Shoh Plitzko, Jürgen M. Baumeister, Wolfgang Schaffer, Miroslava Albert, Sahradha Engel, Benjamin D. |
| Description | Author Affiliation: Engel BD ( Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany baumeist@biochem.mpg.de engelben@biochem.mpg.de.); Schaffer M ( Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany.); Albert S ( Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany.); Asano S ( Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany.); Plitzko JM ( Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany.); Baumeister W ( Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany baumeist@biochem.mpg.de engelben@biochem.mpg.de.); |
| Abstract | We acquired molecular-resolution structures of the Golgi within its native cellular environment. Vitreous Chlamydomonas cells were thinned by cryo-focused ion beam milling and then visualized by cryo-electron tomography. These tomograms revealed structures within the Golgi cisternae that have not been seen before. Narrow trans-Golgi lumina were spanned by asymmetric membrane-associated protein arrays that had â ¼6-nm lateral periodicity. Subtomogram averaging showed that the arrays may determine the narrow central spacing of the trans-Golgi cisternae through zipper-like interactions, thereby forcing cargo to the trans-Golgi periphery. Additionally, we observed dense granular aggregates within cisternae and intracisternal filament bundles associated with trans-Golgi buds. These native in situ structures provide new molecular insights into Golgi architecture and function. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 36 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Algal Proteins Metabolism Chlamydomonas Reinhardtii Golgi Apparatus Membrane Proteins Ultrastructure Cryoelectron Microscopy Electron Microscope Tomography Models, Anatomic Models, Biological Protein Transport Trans-Golgi Network Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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