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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Congar, P. Represa, A. Chevassus-au-louis, N. Ben-ari, Y. Gaïarsa, J. L. |
| Description | Author Affiliation: Chevassus-Au-Louis N ( Institut National de la Santé et de la Recherche Médicale U29, Université Paris 5 René Descartes, 123 Boulevard de Port Royal, 75 674 Paris cedex 14, France. chevassus@cochin.inserm.fr); |
| Abstract | Neuronal migration disorders have been involved in various pathologies, including epilepsy, but the properties of the neural networks underlying disorders have not been determined. In the present study, patch clamp recordings were made from intrahippocampal heterotopic as well as from neocortical and hippocampal neurons from brain slices of rats with prenatally methylazoxymethanol-induced cortical malformation. We report that heterotopic neurons have morphometrical parameters and cellular properties of neocortical supragranular neurons and are integrated in both neocortical and hippocampal networks. Thus, stimulation of the white matter induces both antidromic and orthodromic response in heterotopic and neocortical neurons. Stimulation of hippocampal afferents evokes a monosynaptic response in the majority of heterotopic neurons and a polysynaptic all-or-none epileptiform burst in the presence of bicuculline to block gamma-aminobutyric acid type A inhibition. Furthermore, hippocampal paroxysmal activity generated by bath application of bicuculline can spread directly to the neocortex via the heterotopia in methylazoxymethanol-treated but not in naive rats. We conclude that heterotopias form a functional bridge between the limbic system and the neocortex, providing a substrate for pathological conditions. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 17 |
| Volume Number | 95 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1998-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Movement Hippocampus Abnormalities Neocortex Pyramidal Cells Physiology Action Potentials Animals Drug Effects Electric Stimulation Electrophysiology Physiopathology Methylazoxymethanol Acetate Analogs & Derivatives Toxicity Nerve Net Cytology Patch-Clamp Techniques Pregnancy Rats, Wistar Teratogens Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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