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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Levine, E. S. Plummer, M. R. Crozier, R. A. Black, I. B. |
| Description | Author Affiliation: Levine ES ( Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School/University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA.); |
| Abstract | Neurotrophins (NTs) have recently been found to regulate synaptic transmission in the hippocampus. Whole-cell and single-channel recordings from cultured hippocampal neurons revealed a mechanism responsible for enhanced synaptic strength. Specifically, brain-derived neurotrophic factor augmented glutamate-evoked, but not acetylcholine-evoked, currents 3-fold and increased N-methyl-D-aspartic acid (NMDA) receptor open probability. Activation of trkB NT receptors was critical, as glutamate currents were not affected by nerve growth factor or NT-3, and increased open probability was prevented by the tyrosine kinase inhibitor K-252a. In addition, the NMDA receptor antagonist MK-801 blocked brain-derived neurotrophic factor enhancement of synaptic transmission, further suggesting that NTs modulate synaptic efficacy via changes in NMDA receptor function. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 17 |
| Volume Number | 95 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1998-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Brain-Derived Neurotrophic Factor Pharmacology Hippocampus Drug Effects Physiology Receptors, N-Methyl-D-Aspartate Synaptic Transmission Acetylcholine Animals Cells, Cultured Dizocilpine Maleate Glutamic Acid Cytology N-Methylaspartate Nerve Growth Factors Neurotrophin 3 Antagonists & Inhibitors Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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