NDLI: AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice.

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AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice.

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AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Perkins, A. Nottoli, T. Zhang, J. Williams, T. Hagopian-donaldson, S.
Description	Author Affiliation: Nottoli T ( Department of Molecular, Cellular, and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA.);
Abstract	The homozygous disruption of the mouse AP-2 gene yields a complex and lethal phenotype that results from defective development of the neural tube, head, and body wall. The severe and pleiotropic developmental abnormalities observed in the knockout mouse suggested that AP-2 may regulate several morphogenic pathways. To uncouple the individual developmental mechanisms that are dependent on AP-2, we have now analyzed chimeric mice composed of both wild-type and AP-2-null cells. The phenotypes obtained from these chimeras indicate that there is an independent requirement for AP-2 in the formation of the neural tube, body wall, and craniofacial skeleton. In addition, these studies reveal that AP-2 exerts a major influence on eye formation, which is a critical new role for AP-2 that was masked previously in the knockout mice. Furthermore, we also have uncovered an unexpected influence of AP-2 on limb pattern formation; this influence is typified by major limb duplications. The range of phenotypes observed in the chimeras displays a significant overlap with those caused by teratogenic levels of retinoic acid, strongly suggesting that AP-2 is an important component of the mechanism of action of this morphogen.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Genetics Embryonic And Fetal Development Gene Expression Regulation, Developmental Morphogenesis Transcription Factors Animals Chimera Extremities Embryology Eye Mice Mice, Knockout Transcription Factor AP-2 Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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