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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Foy, M. R. Baudry, M. Bi, R. Broutman, G. Thompson, R. F. |
| Description | Author Affiliation: Bi R ( Neuroscience Program, University of Southern California, Los Angeles, CA 90089-2520, USA.); |
| Abstract | Estrogen replacement therapy in women is associated with improvement of cognitive deficits and reduced incidence of Alzheimer's disease. The present study indicates that estrogen is neuroprotective against N-methyl-d-aspartate (NMDA)- and kainate-mediated neurotoxicity, an effect mediated by tyrosine kinase/mitogen-activated protein kinase (MAPK) pathways. Estrogen also stimulates tyrosine phosphorylation of NMDA receptors via an src tyrosine kinase/MAPK pathway. Finally, estrogen-mediated enhancement of long-term potentiation in hippocampal slices is mediated by activation of an src tyrosine kinase pathway. Thus, estrogen, by activating an src tyrosine kinase and the extracellular signal-related protein kinase/MAPK signaling pathway, both enhances NMDA receptor function and long-term potentiation and retains neuroprotective properties against excitotoxicity. These findings warrant further evaluation of the usefulness of estrogenic compounds for the treatment of Alzheimer's disease and other neurodegenerative diseases. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 7 |
| Volume Number | 97 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2000-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Estrogens Pharmacology Hippocampus Drug Effects MAP Kinase Signaling System Protein-Tyrosine Kinases Metabolism Action Potentials Alzheimer Disease Drug Therapy Animals Therapeutic Use Enzymology Physiology In Vitro Techniques Phosphorylation Receptors, N-Methyl-D-Aspartate Antagonists & Inhibitors Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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