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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Luini, Walter Riboldi, Elena Transidico, Pietro Pinza, Mario Mancini, Francesca Sozzani, Silvano Bernasconi, Sergio Mantovani, Alberto Frascaroli, Giada Guglielmotti, Angelo Milanese, Claudio |
| Description | Author Affiliation: Riboldi E ( Mario Negri Institute for Pharmacological Research, Via Eritrea 62, Milan 20157, Italy.) |
| Abstract | 1. The present study was aimed to investigate the effect of benzydamine, an anti-inflammatory drug devoid of activity on arachidonic acid metabolism, on monocyte chemotaxis and to define the possible biochemical correlates of activity. 2. Benzydamine inhibited monocyte chemotaxis in response to three classes of chemoattractants: the prototypic CC-chemokine CCL2 (MCP-1), the microbial product fMLP and the complement cascade component C5a. The effect was dose-dependent with IC50's of 100, 50 and 45 microm for MCP-1/CCL2, fMLP and C5a, respectively. At the dose of 100 microm, the effect resulted in a 50+/-10% inhibition of MCP-1/CCL2-induced chemotaxis and 53+/-6 and 54+/-5% inhibitions of chemotaxis in response of fMLP and C5a, respectively (n=3). 3. Receptor expression as well as calcium fluxes in response to chemoattractants were not affected by benzydamine. 4. Benzydamine strongly inhibited chemoattractant-induced activation of the mitogen-activated protein kinase (MAPK) ERK1/2, and of its upstream activator kinase MEK1/2. ERK1/12 activation in response to chemoattractants was 89-98% inhibited by a 100 microm concentration of benzydamine with an IC50 of 30 microm. 5. Under the same experimental conditions, pretreatment with 100 microm benzydamine caused a 75-89% inhibition of p38 activation (IC50 25 microm). 6. These results indicate that the anti-inflammatory activity of benzydamine is exerted at multiple levels, including monocyte migration to chemotactic factors associated to a blockage of ERK and p38 MAPK pathways. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 2 |
| Volume Number | 140 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2003-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Benzydamine Pharmacology Cell Movement Drug Effects Chemotactic Factors Mitogen-Activated Protein Kinases Metabolism Monocytes Chemokine CCL2 Chemotaxis Complement C5a Dose-Response Relationship, Drug Enzyme Activation MAP Kinase Kinase 1 MAP Kinase Kinase 2 Mitogen-Activated Protein Kinase 1 Antagonists & Inhibitors Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases Cytology Enzymology N-Formylmethionine Leucyl-Phenylalanine Protein-Tyrosine Kinases P38 Mitogen-Activated Protein Kinases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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