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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Essand, M. Lee, B. Wolfgang, C. D. Pastan, I. Vincent, J. J. |
| Description | Author Affiliation: Wolfgang CD ( Laboratory of Molecular Biology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.); |
| Abstract | Previously, we identified the expression of a prostate-specific form of T cell receptor gamma chain (TCRgamma) mRNA in the human prostate and demonstrated that it originates from epithelial cells and not from infiltrating T lymphocytes. Here, we show that this prostate-specific transcript is also expressed in three breast cancer cell lines and breast cancer tissues. Analysis of the cDNA sequence predicts that this transcript can encode two protein products of 7 and 13 kDa, and in vitro translation experiments showed that both proteins were made. The longer ORF encodes a 13-kDa truncated version of TCRgamma, whereas the shorter alternative reading frame encodes a 7-kDa protein with five leucine residues in heptad repeats followed by a basic region. Studies with specific antibodies against each protein product revealed that both prostate and breast cancer cells contain only the 7-kDa protein, which is located in the nucleus. We have named this protein TCRgamma alternate reading frame protein (TARP). These results demonstrate that an alternative protein product is encoded by the TCRgamma locus in cells other than T lymphocytes. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 17 |
| Volume Number | 97 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2000-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Breast Neoplasms Metabolism Genes, T-Cell Receptor Gamma Genetics Nuclear Proteins Open Reading Frames Prostatic Neoplasms Amino Acid Sequence Breast Pathology Cell Nucleus Chemistry Molecular Sequence Data Molecular Weight Mutation Organ Specificity Protein Biosynthesis RNA, Messenger Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Tumor Cells, Cultured Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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