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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Barbel, S. Moore, A. W. Jan, Y. N. Jan, L. Y. |
| Description | Author Affiliation: Moore AW ( Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143-0725, USA.); |
| Abstract | The basic helix-loop-helix (bHLH) transcription factors play important roles in the specification of tissue type during the development of animals. We have used the information contained in the recently published genomic sequence of Drosophila melanogaster to identify 12 additional bHLH proteins. By sequence analysis we have assigned these proteins to families defined by Atonal, Hairy-Enhancer of Split, Hand, p48, Mesp, MYC/USF, and the bHLH-Per, Arnt, Sim (PAS) domain. In addition, one single protein represents a unique family of bHLH proteins. mRNA in situ analysis demonstrates that the genes encoding these proteins are expressed in several tissue types but are particularly concentrated in the developing nervous system and mesoderm. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 19 |
| Volume Number | 97 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2000-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Drosophila Genetics Genome Helix-Loop-Helix Motifs Amino Acid Sequence Animals Mesoderm Molecular Sequence Data Salivary Glands Metabolism Sequence Homology, Amino Acid Vertebrates Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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