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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Leitner, O. Teitelbaum, D. Sela, M. Aharoni, R. Arnon, R. Meshorer, A. |
| Description | Author Affiliation: Aharoni R ( Departments of Immunology and Biological Services, The Weizmann Institute of Science, Rehovot 76100, Israel.); |
| Abstract | This study addresses the issue of the effect of immunomodulating therapies in the target organ-the central nervous system (CNS)-in the case of multiple sclerosis. Copolymer 1 (Cop 1, Copaxone, glatiramer acetate), an approved drug for the treatment of multiple sclerosis, is a potent inducer of Th2 regulatory cells in both mice and humans. Highly reactive Cop 1-specific T cell lines that secrete IL-4, IL-5, IL-6, IL-10, and transforming growth factor-beta in response to Cop 1 and crossreact with myelin basic protein (MBP) at the level of Th2 cytokine secretion were established from both brains and spinal cords of Cop 1-treated mice. In contrast, no reactivity to the control antigen lysozyme could be obtained in lymphocytes isolated from CNS of mice injected with lysozyme. Adoptively transferred labeled Cop 1-specific suppressor cells were found in brain sections 7 and 10 days after their injection to the periphery, whereas lysozyme-specific cells were absent in the CNS. Hence, Cop 1-induced Th2 cells cross the blood-brain barrier and accumulate in the CNS, where they can be stimulated in situ by MBP and thereby exert therapeutic effects in the diseased organ. This therapeutic effect was manifested, in brains of experimental autoimmune encephalomyelitis-induced mice, by a decrease in the inflammatory cytokine interferon-gamma and by secretion of the anti-inflammatory cytokine IL-10 in response to the autoantigen MBP. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 21 |
| Volume Number | 97 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2000-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adjuvants, Immunologic Administration & Dosage Central Nervous System Pathology Encephalomyelitis, Autoimmune, Experimental Prevention & Control Peptides Immunology Th2 Cells Cytology Adoptive Transfer Animals Secretion Cytokines Fluorescent Dyes Glatiramer Acetate Mice Mice, Inbred BALB C Muramidase Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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