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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hyman, B. T. Xia, M. Q. Rebeck, G. W. Bacskai, B. J. Strickland, D. K. |
| Description | Author Affiliation: Bacskai BJ ( Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital East, Charlestown, MA 02129, USA.); |
| Abstract | The low density lipoprotein receptor-related protein (LRP) is an endocytic receptor that is a member of the low density lipoprotein receptor family. We report that the LRP ligand, activated alpha(2)-macroglobulin (alpha(2)M*), induces robust calcium influx in cultured primary neurons, but not in nonneuronal LRP-containing cells in the same culture. The calcium influx is mediated through N-methyl-d-aspartate receptor channels, which explains the neuron specificity of the response. Microapplication of alpha(2)M* leads to a localized response at the site of application that dissipates rapidly, suggesting that the calcium signal is temporally and spatially discrete. Calcium influx to alpha(2)M* is blocked by the physiological LRP inhibitor, receptor-associated protein. Bivalent antibodies to the extracellular domain of LRP, but not Fab fragments of the same antibody, cause calcium influx, indicating that the response is specific to LRP and may require dimerization of the receptor. Thus, LRP is an endocytic receptor with a novel signaling role. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 21 |
| Volume Number | 97 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2000-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Calcium Signaling Physiology Endocytosis Neurons Metabolism Receptors, Immunologic Receptors, N-Methyl-D-Aspartate Animals Calcium Channel Blockers Pharmacology Cells, Cultured Dizocilpine Maleate Excitatory Amino Acid Antagonists Low Density Lipoprotein Receptor-Related Protein-1 Mice Microscopy, Confocal Antagonists & Inhibitors Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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