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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mohr, E. Fuhrmann, C. Prakash, N. Buck, F. Richter, D. Vieluf, K. |
| Description | Author Affiliation: Mohr E ( Universität Hamburg, Institut für Zellbiochemie und klinische Neurobiologie, Martinistrasse 52, 20246 Hamburg, Germany. emohr@uke.uni-hamburg.de); |
| Abstract | mRNA localization is a complex pathway. Besides mRNA sorting per se, this process includes aspects of regulated translation. It requires protein factors that interact with defined sequences (or sequence motifs) of the transcript, and the protein/RNA complexes are finally guided along the cytoskeleton to their ultimate destinations. The mRNA encoding the vasopressin (VP) precursor protein is localized to the nerve cell processes in vivo and in primary cultured nerve cells. Sorting of VP transcripts to dendrites is mediated by the last 395 nucleotides of the mRNA, the dendritic localizer sequence, and it depends on intact microtubules. In vitro interaction studies with cytosolic extracts demonstrated specific binding of a protein, enriched in nerve cell tissues, to the radiolabeled dendritic localizer sequence probe. Biochemical purification revealed that this protein is the multifunctional poly(A)-binding protein (PABP). It is well known for its ability to bind with high affinity to poly(A) tails of mRNAs, prerequisite for mRNA stabilization and stimulation of translational initiation, respectively. With lower affinities, PABP can also associate with non-poly(A) sequences. The physiological consequences of these PABP/RNA interactions are far from clear but may include functions such as translational silencing. Presumably, the translational state of mRNAs subject to dendritic sorting is influenced by external stimuli. PABP thus could be a component required to regulate local synthesis of the VP precursor and possibly of other proteins. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 13 |
| Volume Number | 98 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2001-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Brain Metabolism Neurons RNA, Messenger Genetics RNA-Binding Proteins Vasopressins Amino Acid Sequence Animals Chromatography, Affinity Cloning, Molecular Dendrites Gene Expression Regulation Molecular Sequence Data Poly(A)-Binding Proteins Protein Biosynthesis Protein Precursors Chemistry Isolation & Purification Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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