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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Padilla, P. A. Roth, M. B. |
| Description | Author Affiliation: Padilla PA ( Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.); |
| Abstract | Continuous exposure to oxygen is essential for nearly all vertebrates. We found that embryos of the zebrafish Danio rerio can survive for 24 h in the absence of oxygen (anoxia, 0% O2). In anoxia, zebrafish entered a state of suspended animation where all microscopically observable movement ceased, including cell division, developmental progression, and motility. Animals that had developed a heartbeat before anoxic exposure showed no evidence of a heartbeat until return to terrestrial atmosphere (normoxia, 20.8% O2). In analyzing cell-cycle changes of rapidly dividing blastomeres exposed to anoxia, we found that no cells arrested in mitosis. This is in sharp contrast to similarly staged normoxic embryos that consistently contain more than 15% of cells in mitosis. Flow cytometry analysis revealed that blastomeres arrested during the S and G2 phases of the cell cycle. This work indicates that survival of oxygen deprivation in vertebrates involves the reduction of diverse processes, such as cardiac function and cell-cycle progression, thus allowing energy supply to be matched by energy demands. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 13 |
| Volume Number | 98 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2001-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Blastomeres Physiology Cell Cycle Embryo, Nonmammalian Zebrafish Embryology Anaerobiosis Animals Blastocyst Cytology Body Patterning Cell Nucleus Ultrastructure Flow Cytometry Gastrula Anoxia Interphase Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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