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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Fedele, M. Vecchione, A. Battista, S. Baldassarre, G. Klein-szanto, A. J. Azimi, N. Santoro, M. Waldmann, T. A. Fusco, A. Croce, C. M. |
| Description | Author Affiliation: Baldassarre G ( Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA.); |
| Abstract | Rearrangements of the high mobility group protein I-C (HMGI-C) gene, consisting in the loss of the carboxyl-terminal tail, have been frequently detected in benign human tumors of mesenchymal origin. We have previously demonstrated that transgenic (TG) mice carrying a truncated HMGI-C construct (HMGI-C/T) exhibit a giant phenotype together with a predominantly abdominal/pelvic lipomatosis. Here, we report that HMGI-C/T TG mice develop natural killer (NK)-T/NK cell lymphomas starting from 12 months of age. We found an increased expression of IL-2 and IL-15 proteins and their receptors in these lymphomas, and we demonstrate that HMGI-C/T protein positively regulates their expression in vitro. Therefore, the HMGI-C/T-mediated chronic stimulation of the IL-2/IL-15 pathway could be responsible for the onset of NK-T/NK cell lymphomas in HMGI-C/T TG mice. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 14 |
| Volume Number | 98 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2001-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | High Mobility Group Proteins Genetics Interleukin-15 Immunology Interleukin-2 Lymphoma, T-Cell Animals Cell Transformation, Neoplastic Genetic Predisposition To Disease Killer Cells, Natural Pathology Etiology Mice Mice, Transgenic Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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