NDLI: Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination.

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Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy.

Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase.

The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia

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Deciphering the design of the tropomyosin molecule.

Long-term plasticity in interneurons of the dentate gyrus.

The highly recombinogenic bz locus lies in an unusually gene-rich region of the maize genome.

Antagonistic forces generated by myosin II and cytoplasmic dynein regulate microtubule turnover, movement, and organization in interphase cells.

Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: identification of an acyldisulfide-linked protein--protein conjugate that is functionally analogous to the ubiquitin/E1 complex.

In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei.

Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation.

Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome

Cloning and functional analysis of two gibberellin 3 beta -hydroxylase genes that are differently expressed during the growth of rice.

Genome-wide gene expression profiles of the developing mouse hippocampus.

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.

Location and properties of metal-binding sites on the human prion protein

Regulatory function of in vivo anergized CD4(+) T cells.

Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation.

A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.

Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells.

Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development.

Energy-driven subunit rotation at the interface between subunit a and the c oligomer in the $F_{O}$ sector of Escherichia coli ATP synthase

Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B.

Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein.

An antisense approach to phenotype-based gene cloning in Tetrahymena.

DNA bending by an adenine--thymine tract and its role in gene regulation.

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

Old yellow enzyme: reduction of nitrate esters, glycerin trinitrate, and propylene 1,2-dinitrate.

Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA.

Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice.

Identification of an autoimmune serum containing antibodies against the Barr body.

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease.

Folliculostellate cell network: a route for long-distance communication in the anterior pituitary.

Intrinsic noise in gene regulatory networks.

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Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans.

Mechanism of DNA polymerase II-mediated frameshift mutagenesis.

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4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma.

Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster.

Contact interactions between epitheliocytes and fibroblasts: formation of heterotypic cadherin-containing adhesion sites is accompanied by local cytoskeletal reorganization.

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining.

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.

The trimer-of-hairpins motif in membrane fusion: Visna virus.

Force and kinetic barriers to unzipping of the DNA double helix.

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Sir3-dependent assembly of supramolecular chromatin structures in vitro.

Antibodies with infinite affinity.

Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.

Tuning DNA 'strings': modulating the rate of DNA replication with mechanical tension.

Rolling-circle transposons in eukaryotes.

The endopolyphosphatase gene: Essential in Saccharomyces cerevisiae

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IL-7 is critical for homeostatic proliferation and survival of naive T cells.

Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways.

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A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity.

Lightness constancy in primary visual cortex.

The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity.

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Historical overview: searching for replication help in all of the rec places.

Rescue of arrested replication forks by homologous recombination.

Circles: the replication-recombination-chromosome segregation connection.

Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination.

Effects of mutations involving cell division, recombination, and chromosome dimer resolution on a priA2::kan mutant.

RecA protein promotes the regression of stalled replication forks in vitro.

Topological challenges to DNA replication: conformations at the fork.

Rescue of stalled replication forks by RecG: simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation.

Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled.

Single-strand interruptions in replicating chromosomes cause double-strand breaks.

Handoff from recombinase to replisome: insights from transposition.

Break-induced replication: a review and an example in budding yeast.

Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity.

Evidence that replication fork components catalyze establishment of cohesion between sister chromatids.

Rad52 forms DNA repair and recombination centers during S phase.

A yeast gene, MGS1, encoding a DNA-dependent AAA(+) ATPase is required to maintain genome stability.

The tight linkage between DNA replication and double-strand break repair in bacteriophage T4.

Mediator proteins orchestrate enzyme-ssDNA assembly during T4 recombination-dependent DNA replication and repair.

Two recombination-dependent DNA replication pathways of bacteriophage T4, and their roles in mutagenesis and horizontal gene transfer.

Bacteriophage T4 gene 41 helicase and gene 59 helicase-loading protein: a versatile couple with roles in replication and recombination.

Instability of repetitive DNA sequences: the role of replication in multiple mechanisms.

Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences.

Stationary-phase mutation in the bacterial chromosome: recombination protein and DNA polymerase IV dependence.

Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination.

Roles of DNA polymerases V and II in SOS-induced error-prone and error-free repair in Escherichia coli.

Accuracy of lesion bypass by yeast and human DNA polymerase eta.

ATP bound to the origin recognition complex is important for preRC formation.

Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer.

Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I.

Defining the roles of individual residues in the single-stranded DNA binding site of PcrA helicase.

Homologous DNA recombination in vertebrate cells.

Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe.

Manipulating the mammalian genome by homologous recombination.

Assembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosis.

Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA.

Homologous genetic recombination as an intrinsic dynamic property of a DNA structure induced by RecA/Rad51-family proteins: a possible advantage of DNA over RNA as genomic material.

The synaptic activity of HsDmc1, a human recombination protein specific to meiosis.

Complex formation by the human RAD51C and XRCC3 recombination repair proteins.

Rad54 protein stimulates the postsynaptic phase of Rad51 protein-mediated DNA strand exchange.

The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA.

DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination.

Excited-state dynamics in photosystem II: insights from the x-ray crystal structure.

Computer-modeling origin of a simple genetic apparatus.

Demonstration of the extrinsic coagulation pathway in teleostei: identification of zebrafish coagulation factor VII.

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Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sutton, M. D. Walker, G. C.
Description	Author Affiliation: Sutton MD ( Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.);
Abstract	Two important and timely questions with respect to DNA replication, DNA recombination, and DNA repair are: (i) what controls which DNA polymerase gains access to a particular primer-terminus, and (ii) what determines whether a DNA polymerase hands off its DNA substrate to either a different DNA polymerase or to a different protein(s) for the completion of the specific biological process? These questions have taken on added importance in light of the fact that the number of known template-dependent DNA polymerases in both eukaryotes and in prokaryotes has grown tremendously in the past two years. Most notably, the current list now includes a completely new family of enzymes that are capable of replicating imperfect DNA templates. This UmuC-DinB-Rad30-Rev1 superfamily of DNA polymerases has members in all three kingdoms of life. Members of this family have recently received a great deal of attention due to the roles they play in translesion DNA synthesis (TLS), the potentially mutagenic replication over DNA lesions that act as potent blocks to continued replication catalyzed by replicative DNA polymerases. Here, we have attempted to summarize our current understanding of the regulation of action of DNA polymerases with respect to their roles in DNA replication, TLS, DNA repair, DNA recombination, and cell cycle progression. In particular, we discuss these issues in the context of the Gram-negative bacterium, Escherichia coli, that contains a DNA polymerase (Pol V) known to participate in most, if not all, of these processes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Repair DNA Replication DNA-Directed DNA Polymerase Metabolism Escherichia Coli Proteins Recombination, Genetic Animals Bacterial Proteins DNA Damage DNA Polymerase III DNA Primers Escherichia Coli Enzymology Eukaryotic Cells Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Prokaryotic Cells Rec A Recombinases Signal Transduction Templates, Genetic Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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