NDLI: Stationary-phase mutation in the bacterial chromosome: recombination protein and DNA polymerase IV dependence.

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Stationary-phase mutation in the bacterial chromosome: recombination protein and DNA polymerase IV dependence.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lombardo, M. J. Bull, H. J. Rosenberg, S. M.
Description	Author Affiliation: Bull HJ ( Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-3411, USA.);
Abstract	Several microbial systems have been shown to yield advantageous mutations in slowly growing or nongrowing cultures. In one assay system, the stationary-phase mutation mechanism differs from growth-dependent mutation, demonstrating that the two are different processes. This system assays reversion of a lac frameshift allele on an F' plasmid in Escherichia coli. The stationary-phase mutation mechanism at lac requires recombination proteins of the RecBCD double-strand-break repair system and the inducible error-prone DNA polymerase IV, and the mutations are mostly -1 deletions in small mononucleotide repeats. This mutation mechanism is proposed to occur by DNA polymerase errors made during replication primed by recombinational double-strand-break repair. It has been suggested that this mechanism is confined to the F plasmid. However, the cells that acquire the adaptive mutations show hypermutation of unrelated chromosomal genes, suggesting that chromosomal sites also might experience recombination protein-dependent stationary-phase mutation. Here we test directly whether the stationary-phase mutations in the bacterial chromosome also occur via a recombination protein- and pol IV-dependent mechanism. We describe an assay for chromosomal mutation in cells carrying the F' lac. We show that the chromosomal mutation is recombination protein- and pol IV-dependent and also is associated with general hypermutation. The data indicate that, at least in these male cells, recombination protein-dependent stationary-phase mutation is a mechanism of general inducible genetic change capable of affecting genes in the bacterial chromosome.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chromosomes, Bacterial DNA Polymerase Beta Metabolism Escherichia Coli Proteins Recombination, Genetic Alleles Bacterial Proteins Genetics Endodeoxyribonucleases Exodeoxyribonuclease V Exodeoxyribonucleases Genes, Bacterial Lactose Mutagenesis Rec A Recombinases Repressor Proteins Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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