NDLI: Amino acid runs in eukaryotic proteomes and disease associations

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2002 Volume: 99 Issue: 26

Year: 2002 Volume: 99 Issue: 25

Year: 2002 Volume: 99 Issue: 24

Year: 2002 Volume: 99 Issue: 23

Year: 2002 Volume: 99 Issue: 22

Year: 2002 Volume: 99 Issue: 21

Year: 2002 Volume: 99 Issue: 20

Year: 2002 Volume: 99 Issue: 19

Year: 2002 Volume: 99 Issue: 18

Year: 2002 Volume: 99 Issue: 17

Year: 2002 Volume: 99 Issue: 16

Year: 2002 Volume: 99 Issue: 15

Year: 2002 Volume: 99 Issue: 14

Year: 2002 Volume: 99 Issue: 13

Year: 2002 Volume: 99 Issue: 12

Year: 2002 Volume: 99 Issue: 11

Year: 2002 Volume: 99 Issue: 10

Year: 2002 Volume: 99 Issue: 9

Year: 2002 Volume: 99 Issue: 8

Year: 2002 Volume: 99 Issue: 7

Year: 2002 Volume: 99 Issue: 6

Year: 2002 Volume: 99 Issue: 5

Year: 2002 Volume: 99 Issue: 4

Year: 2002 Volume: 99 Issue: Suppl 4

Year: 2002 Volume: 99 Issue: 3

Year: 2002 Volume: 99 Issue: Suppl 3

Year: 2002 Volume: 99 Issue: 2

Year: 2002 Volume: 99 Issue: Suppl 2

Year: 2002 Volume: 99 Issue: 1

Receptor sensitivity in bacterial chemotaxis.

Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice invivo.

Tumor attenuation by combined heparan sulfate and polyamine depletion.

On the activation of soluble guanylyl cyclase by nitric oxide.

Sequence evolution and copy number of Ty1-copia retrotransposons in diverse plant genomes.

Decreased intracellular calcium mediates the histamine $H_{3}-receptor-induced$ attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings

Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter.

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.

Femtosecond dynamics of rubredoxin: tryptophan solvation and resonance energy transfer in the protein.

Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation.

Regulatory DNA required for vnd/NK-2 homeobox gene expression pattern in neuroblasts.

The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice.

Efficient bacterial transcription of DNA nanocircle vectors with optimized single-stranded promoters.

A recombinant vaccine expressed in the milk of transgenic mice protects Aotus monkeys from a lethal challenge with Plasmodium falciparum.

Differential aggregation of the Trembler and Trembler J mutants of peripheral myelin protein 22.

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent.

Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion.

Optical imaging of Renilla luciferase reporter gene expression in living mice.

Control of Epstein-Barr virus reactivation by activated CD40 and viral latent membrane protein 1.

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.

Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p

Generation of ultra-intense single-cycle laser pulses by using photon deceleration.

Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis.

Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene.

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo.

Mice and humans perceive multiharmonic communication sounds in the same way.

Hpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in Listeria.

High levels of Y-chromosome nucleotide diversity in the genus Pan.

Integration of Shaker-type $K^{+}$ channel, KAT1, into the endoplasmic reticulum membrane: Synergistic insertion of voltage-sensing segments, S3–S4, and independent insertion of pore-forming segments, S5–P–S6

A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2.

Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.

Identification of a potent antidiuretic factor acting on beetle Malpighian tubules.

CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.

Arabidopsis gp91phox homologues AtrbohD and AtrbohF are required for accumulation of reactive oxygen intermediates in the plant defense response.

Functional self-association of von Willebrand factor during platelet adhesion under flow.

Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage

Evidence of positive selection acting at the human dopamine receptor D4 gene locus.

Functional MRI detection of pharmacologically induced memory impairment.

Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans

Dorsal anterior cingulate cortex: a role in reward-based decision making.

Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.

Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response.

Short interspersed transposable elements (SINEs) are excluded from imprinted regions in the human genome.

EDEN-dependent translational repression of maternal mRNAs is conserved between Xenopus and Drosophila.

The B2 element of the Saccharomyces cerevisiaeARS1 origin of replication requires specific sequences to facilitate pre-RC formation

Biosensors from conjugated polyelectrolyte complexes.

Profile of the genes expressed in the human peripheral retina, macula, and retinal pigment epithelium determined through serial analysis of gene expression (SAGE).

Structure determination of micelle-like intermediates in amyloid beta -protein fibril assembly by using small angle neutron scattering.

DNA sequence recognition in the minor groove by crosslinked polyamides: The effect of N-terminal head group and linker length on binding affinity and specificity.

Quaternary structure of human fatty acid synthase by electron cryomicroscopy.

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture.

Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes.

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus.

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides.

Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis.

Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.

Effect of HIV integrase inhibitors on the RAG1/2 recombinase.

Mariner-like transposases are widespread and diverse in flowering plants.

The genome sequence of the facultative intracellular pathogen Brucella melitensis.

Exploring the folding landscape of a structured RNA.

High-pressure transformations in xenon hydrates.

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization.

Rapid activation of $G_{2}/M$ checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase

Molecular immunolabeling with recombinant single-chain variable fragment (scFv) antibodies designed with metal-binding domains.

Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites.

A single Hox3 gene with composite bicoid and zerknullt expression characteristics in non-Cyclorrhaphan flies.

Insect NMDA receptors mediate juvenile hormone biosynthesis.

The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase

Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.

The glycosynapse.

Recruitment of intron-encoded and co-opted proteins in splicing of the bI3 group I intron RNA.

Functional requirement of aquaporin-5 in plasma membranes of sweat glands.

Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.

A fragment of human TrpRS as a potent antagonist of ocular angiogenesis.

A human aminoacyl-tRNA synthetase as a regulator of angiogenesis.

Temporal binding via cortical coincidence detection of specific and nonspecific thalamocortical inputs: a voltage-dependent dye-imaging study in mouse brain slices.

Brain signatures of artificial language processing: evidence challenging the critical period hypothesis.

The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration.

A closer look at the elementary fermions.

Mullerian-inhibiting substance regulates NF-kappa B signaling in the prostate in vitro and in vivo.

Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance.

Brucella melitensis: a nasty bug with hidden credentials for virulence.

Structured intermittent treatment for HIV disease: Necessary concession or premature compromise?

Bacterial chemotaxis and the question of gain.

Dynamin at actin tails.

The large GTPase dynamin regulates actin comet formation and movement in living cells.

Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair.

A role for biliverdin IXalpha in dorsal axis development of Xenopus laevis embryos.

Disappearance of insectivorous birds from tropical forest fragments.

Evolution of sociality in a primitively eusocial lineage of bees.

Amino acid runs in eukaryotic proteomes and disease associations

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use.

Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice.

Phylogenetic relationships among domesticated and wild species of Cucurbita (Cucurbitaceae) inferred from a mitochondrial gene: Implications for crop plant evolution and areas of origin.

Year: 2002 Volume: 99 Issue: Suppl 1

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Amino acid runs in eukaryotic proteomes and disease associations

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gentles, Andrew J. Karlin, Samuel Brocchieri, Luciano Bergman, Aviv Mrazek, Jan
Description	Author Affiliation: Karlin S ( Department of Mathematics, and Center for Computational Genetics and Biological Modeling, Stanford University, Stanford, CA 94305-2125, USA. karlin@math.stanford.edu);
Abstract	We present a comparative proteome analysis of the five complete eukaryotic genomes (human, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, Arabidopsis thaliana), focusing on individual and multiple amino acid runs, charge and hydrophobic runs. We found that human proteins with multiple long runs are often associated with diseases; these include long glutamine runs that induce neurological disorders, various cancers, categories of leukemias (mostly involving chromosomal translocations), and an abundance of Ca(2 +) and K(+) channel proteins. Many human proteins with multiple runs function in development and/or transcription regulation and are Drosophila homeotic homologs. A large number of these proteins are expressed in the nervous system. More than 80% of Drosophila proteins with multiple runs seem to function in transcription regulation. The most frequent amino acid runs in Drosophila sequences occur for glutamine, alanine, and serine, whereas human sequences highlight glutamate, proline, and leucine. The most frequent runs in yeast are of serine, glutamine, and acidic residues. Compared with the other eukaryotic proteomes, amino acid runs are significantly more abundant in the fly. This finding might be interpreted in terms of innate differences in DNA-replication processes, repair mechanisms, DNA-modification systems, and mutational biases. There are striking differences in amino acid runs for glutamine, asparagine, and leucine among the five proteomes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Arabidopsis Genetics Caenorhabditis Elegans Drosophila Melanogaster Genome, Human Genome Saccharomyces Cerevisiae Animals Asparagine Chemistry Glutamine Leucine Serine Species Specificity Transcription, Genetic Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in