NDLI: In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure.

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In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure.

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In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wehrli, Felix W. Hilaire, Luna Zemel, Babette S. Takahashi, Masaya Hwang, Scott N.
Description	Author Affiliation: Takahashi M ( Department of Radiology, University of Pennsylvania Medical Center, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA.);
Abstract	Corticosteroids are in widespread clinical use but are known to have adverse skeletal side effects. Moreover, it is not known how soon these effects become apparent. Here, we describe a longitudinal approach to evaluate the short-term implications of excess corticosteroid exposure by quantitative in vivo magnetic resonance imaging and spectroscopy in conjunction with digital image processing and analysis in a rabbit model. Two-week treatment with dexamethasone induced a significant reduction in trabecular bone volume, which occurred at the expense of uniform trabecular thinning without affecting network architecture. Paralleling the loss in bone volume was conversion of hematopoietic to yellow marrow in the femoral metaphysis and atrophy of the femoral epiphyseal growth plate. This work demonstrates that detailed quantitative morphometric and physiological information can be obtained noninvasively at multiple skeletal locations. The method is likely to eventually replace invasive histomorphometry in that it obviates the need to sacrifice groups of animals at multiple time points. Finally, this work, which was performed on a clinical scanner, has implications for evaluating patients on high-dose steroid treatment.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bone And Bones Drug Effects Dexamethasone Toxicity Animals Bone Marrow Pathology Dose-Response Relationship, Drug Growth Plate Magnetic Resonance Imaging Osteoporosis Etiology Rabbits Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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