NDLI: Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size

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Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size

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Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	O'callaghan, Dermott W. Burgoyne, Robert D. Graham, Margaret E. Mcmahon, Harvey T.
Description	Author Affiliation: Graham ME ( Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom.);
Abstract	Accumulating evidence suggests that the kinetics of release from single secretory vesicles can be regulated and that quantal size can be modified during fast kiss-and-run fusion. Multiple pathways for vesicle retrieval have been identified involving clathrin and dynamin. It has been unclear whether dynamin could participate in a fast kiss-and-run process to reclose a transient fusion pore and thereby limit vesicle release. We have disrupted dynamin function in adrenal chromaffin cells by expression of the amphiphysin Src-homology domain 3 (SH3) or by application of guanosine 5'-[gamma-thio]triphosphate (GTP gamma S), and have monitored single vesicle release events, evoked by digitonin and Ca(2+), by using carbon-fiber amperometry. Under both conditions, there was an increase in mean quantal size accompanying an increase in the half-width of amperometric spikes and a slowing of the fall time. These data suggest the existence of a dynamin-dependent process that can terminate vesicle release under basal conditions. Protein kinase C activation changed release kinetics and decreased quantal size by shortening the release period. The effects of phorbol ester treatment were not prevented by expression of the amphiphysin SH3 domain or by GTP gamma S suggesting the existence of alternative dynamin-independent process underlying fast kiss-and-run exocytosis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	GTP Phosphohydrolases Metabolism Protein Kinase C Animals Chromaffin Cells Dynamins Endocytosis Physiology Enzyme Activation Guanosine 5'-O-(3-Thiotriphosphate) Kinetics Nerve Tissue Proteins Tetradecanoylphorbol Acetate Pharmacology Src Homology Domains Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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