NDLI: The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer.

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The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Clevenger, Charles V. Rycyzyn, Michael A.
Description	Author Affiliation: Rycyzyn MA ( Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.);
Abstract	The nuclear translocation of peptide hormones, such as the somatolactogenic hormone prolactin, after receptor internalization has been widely reported. Prolactin has been demonstrated to interact with cyclophilin B, a member of the immunophilin family of proteins. Cyclophilin B interaction with prolactin potentiated prolactin-induced proliferation, cell growth, and the nuclear retrotransport of prolactin. These effects could be abrogated by the removal of the peptidyl-prolyl isomerase activity of cyclophilin B. Our findings indicate that the intranuclear prolactin/cyclophilin B complex acts as a transcriptional inducer by interacting directly with Stat5, resulting in the removal of the Stat-repressor protein inhibitor of activated Stat 3 (PIAS3), thereby enhancing Stat5 DNA-binding activity and prolactin-induced, Stat5-mediated gene expression.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cyclophilins Metabolism DNA-Binding Proteins Milk Proteins Prolactin Trans-Activators Transcription, Genetic Animals Carrier Proteins Caseins Genetics Cell Division Cell Nucleus Peptidylprolyl Isomerase STAT5 Transcription Factor Tumor Cells, Cultured Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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