NDLI: Genetic basis for systems of skeletal quantitative traits: principal component analysis of the canid skeleton.

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Genetic basis for systems of skeletal quantitative traits: principal component analysis of the canid skeleton.

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Genetic basis for systems of skeletal quantitative traits: principal component analysis of the canid skeleton.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chase, Kevin Adler, Frederick R. Jarvik, Tyler Lorentzen, Travis D. Ostrander, Elaine A. Lark, Karl G. Carrier, David R.
Description	Author Affiliation: Chase K ( University of Utah, Department of Biology, 257 South 1400 East, Room 201, Salt Lake City, UT 84112-0840, USA.);
Abstract	Evolution of mammalian skeletal structure can be rapid and the changes profound, as illustrated by the morphological diversity of the domestic dog. Here we use principal component analysis of skeletal variation in a population of Portuguese Water Dogs to reveal systems of traits defining skeletal structures. This analysis classifies phenotypic variation into independent components that can be used to dissect genetic networks regulating complex biological systems. We show that unlinked quantitative trait loci associated with these principal components individually promote both correlations within structures (e.g., within the skull or among the limb bones) and inverse correlations between structures (e.g., skull vs. limb bones). These quantitative trait loci are consistent with regulatory genes that inhibit growth of some bones while enhancing growth of others. These systems of traits could explain the skeletal differences between divergent breeds such as Greyhounds and Pit Bulls, and even some of the skeletal transformations that characterize the evolution of hominids.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bone And Bones Anatomy & Histology Genetics Quantitative Trait, Heritable Animals DNA Blood Genetic Variation Radiography Skull Species Specificity Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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