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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Seshadri, Rekha Lindler, Luther E. Boyle, Stephen M. Shetty, Jyoti Beanan, Maureen J. Tettelin, Herve Umayam, Lowell Paulsen, Ian T. Brinkac, Lauren M. Riedmuller, Steven Eisen, Jonathan A. Ayodeji, Bola White, Owen Malek, Joel Nelson, William C. Fraser, Claire M. Heidelberg, John F. Read, Timothy D. Dodson, Robert J. Halling, Shirley M. Durkin, A. Scott Hoover, David L. Kraul, Margaret Kolonay, James F. Nelson, Karen E. Daugherty, Sean C. Madupu, Ramana Salzberg, Steven L. Van Aken, Susan E. Deboy, Robert T. Gill, Steven R. |
| Description | Author Affiliation: Paulsen IT ( The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. ipaulsen@tigr.org); |
| Abstract | The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 20 |
| Volume Number | 99 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2002-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Brucella Genetics Genome, Bacterial Alphaproteobacteria Pathogenicity Brucella Melitensis Chromosomes, Bacterial Ultrastructure DNA Transposable Elements Models, Genetic Molecular Sequence Data Open Reading Frames Rhizobium Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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