NDLI: Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2002 Volume: 99 Issue: 26

Year: 2002 Volume: 99 Issue: 25

Year: 2002 Volume: 99 Issue: 24

Year: 2002 Volume: 99 Issue: 23

Year: 2002 Volume: 99 Issue: 22

Year: 2002 Volume: 99 Issue: 21

Evolution of moth sex pheromones via ancestral genes.

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.

An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP.

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium.

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.

Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.

IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.

Subunit rotation of ATP synthase embedded in membranes: a or β subunit rotation relative to the c subunit ring

Solution structure and dynamics of the outer membrane enzyme PagP by NMR.

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.

Three semidominant barley mutants with single amino acid substitutions in the smallest magnesium chelatase subunit form defective $AAA^{+}$ hexamers

Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics.

Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number.

A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity.

X-ray structure of a bifunctional protein kinase in complex with its protein substrate HPr.

Testosterone in utero and at birth dictates how stressful experience will affect learning in adulthood.

On the power of chemical synthesis: immunological evaluation of models for multiantigenic carbohydrate-based cancer vaccines.

Innate recognition of bacteria by a macrophage cytosolic surveillance pathway.

Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae.

Pyrophosphate-producing protein dephosphorylation by HPr kinase/phosphorylase: a relic of early life?

Protonation of non-Watson-Crick base pairs and encapsidation of turnip yellow mosaic virus RNA.

Recognition of the DNA sequence by an inorganic crystal surface.

Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice.

Higher order arrangement of the eukaryotic nuclear bodies.

The function of bursts of spikes during visual fixation in the awake primate lateral geniculate nucleus and primary visual cortex.

Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation.

Combinatorial mutagenesis to restrict amino acid usage in an enzyme to a reduced set.

Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.

Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability.

Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT-1 and NF-kappa B) complexes by antibody-dependent enhancement of macrophage infection by Ross River virus.

Critical points in charged membranes containing cholesterol.

Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus.

A dominant block to HIV-1 replication at reverse transcription in simian cells.

Increased noise as an effect of haploinsufficiency of the tumor-suppressor gene neurofibromatosis type 1 in vitro

Folding free energy function selects native-like protein sequences in the core but not on the surface.

Remarkable compartmentalization of transposable elements and pseudogenes in the heterochromatin of the Tetraodon nigroviridis genome.

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage.

Electrical cues regulate the orientation and frequency of cell division and the rate of wound healing in vivo.

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.

Helix–hairpin–helix motifs confer salt resistance and processivity on chimeric DNA polymerases

Activity patterns in human motion-sensitive areas depend on the interpretation of global motion.

The functional integrity of normally forested landscapes: a proposal for an index of environmental capital.

Small heat-shock proteins regulate membrane lipid polymorphism

Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses.

Bystander effect produced by radiolabeled tumor cells in vivo.

Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes.

Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration.

Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels.

Modeling the Internet's large-scale topology.

Structural analysis of the RSC chromatin-remodeling complex.

CD1d and invariant NKT cells at the human maternal-fetal interface.

Reciprocal developmental regulation of presynaptic ionotropic receptors.

The tomato fer gene encoding a bHLH protein controls iron-uptake responses in roots.

Structure of the single-strand annealing domain of human RAD52 protein.

Natural killer cells attack tumor cells expressing high levels of sialyl Lewis x oligosaccharides.

Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues.

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse.

Amino acid deletions are introduced into the V2 region of gp120 during independent pathogenic simian immunodeficiency virus/HIV chimeric virus (SHIV) infections of rhesus monkeys generating variants that are macrophage tropic.

Error catastrophe and antiviral strategy.

Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy.

B cells develop in the zebrafish pancreas.

DBC2, a candidate for a tumor suppressor gene involved in breast cancer.

Structure and function in rhodopsin: asymmetric reconstitution of rhodopsin in liposomes.

Interruption of antiretroviral therapy to augment immune control of chronic HIV-1 infection: risk without reward.

Structure and function in rhodopsin: a tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants.

Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line.

Climate, changing phenology, and other life history traits: nonlinearity and match-mismatch to the environment.

Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals.

Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer.

The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression.

An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth.

APC-dependent suppression of colon carcinogenesis by PPARgamma.

Natural alleles at a tomato fruit size quantitative trait locus differ by heterochronic regulatory mutations.

Identification of a localization factor for the polar positioning of bacterial structural and regulatory proteins.

Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling.

Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection.

Two regulatory levels of transcriptional gene silencing in Arabidopsis.

Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31.

Natural radioactivity and human mitochondrial DNA mutations.

Structures and stabilities of higher coordinate onium-boronium dications $(X^{+}BH_{3}^{+}$ and $X^{+}BH_{5}^{+};$ X = $NH_{3},$ $PH_{3},$ $H_{2}O,$ and $H_{2}S)$

The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast

Molecular evidence for ecological speciation in tropical habitats.

Predicting the effects of climate change on avian life-history traits.

Transport of nitrated albumin across continuous vascular endothelium.

S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase.

Linkage limits the power of natural selection in Drosophila.

Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior.

A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex.

Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon.

Do SNARE proteins confer specificity for vesicle fusion?

Chemotherapeutic hope on the horizon for Plasmodium vivax malaria?

Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?

Mechanism for saltational shifts in pheromone communication systems.

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.

The discovery of susceptibility genes for mental disorders.

The hidden duplication past of Arabidopsis thaliana.

Temporal expression of seven clock genes in the suprachiasmatic nucleus and the pars tuberalis of the sheep: Evidence for an internal coincidence timer

Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules.

Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules.

Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis.

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection.

HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels.

Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering.

A two-state kinetic model for the unfolding of single molecules by mechanical force.

A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity.

Year: 2002 Volume: 99 Issue: 20

Year: 2002 Volume: 99 Issue: 19

Year: 2002 Volume: 99 Issue: 18

Year: 2002 Volume: 99 Issue: 17

Year: 2002 Volume: 99 Issue: 16

Year: 2002 Volume: 99 Issue: 15

Year: 2002 Volume: 99 Issue: 14

Year: 2002 Volume: 99 Issue: 13

Year: 2002 Volume: 99 Issue: 12

Year: 2002 Volume: 99 Issue: 11

Year: 2002 Volume: 99 Issue: 10

Year: 2002 Volume: 99 Issue: 9

Year: 2002 Volume: 99 Issue: 8

Year: 2002 Volume: 99 Issue: 7

Year: 2002 Volume: 99 Issue: 6

Year: 2002 Volume: 99 Issue: 5

Year: 2002 Volume: 99 Issue: 4

Year: 2002 Volume: 99 Issue: Suppl 4

Year: 2002 Volume: 99 Issue: 3

Year: 2002 Volume: 99 Issue: Suppl 3

Year: 2002 Volume: 99 Issue: 2

Year: 2002 Volume: 99 Issue: Suppl 2

Year: 2002 Volume: 99 Issue: 1

Year: 2002 Volume: 99 Issue: Suppl 1

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Britten, Roy J.
Description	Author Affiliation: Britten RJ ( California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA. rbritten@cco.caltech.edu);
Abstract	Five chimpanzee bacterial artificial chromosome (BAC) sequences (described in GenBank) have been compared with the best matching regions of the human genome sequence to assay the amount and kind of DNA divergence. The conclusion is the old saw that we share 98.5% of our DNA sequence with chimpanzee is probably in error. For this sample, a better estimate would be that 95% of the base pairs are exactly shared between chimpanzee and human DNA. In this sample of 779 kb, the divergence due to base substitution is 1.4%, and there is an additional 3.4% difference due to the presence of indels. The gaps in alignment are present in about equal amounts in the chimp and human sequences. They occur equally in repeated and nonrepeated sequences, as detected by REPEATMASKER (http://ftp.genome.washington.edu/RM/RepeatMasker.html).
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Genetics Evolution, Molecular Pan Troglodytes Animals Chromosomes, Artificial, Bacterial DNA Transposable Elements Gene Rearrangement Sequence Alignment Statistics & Numerical Data Sequence Deletion Sequence Homology, Nucleic Acid Species Specificity Comparative Study Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in