NDLI: Male-specific lethal complex of Drosophila targets activated regions of the X chromosome for chromatin remodeling.

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Male-specific lethal complex of Drosophila targets activated regions of the X chromosome for chromatin remodeling.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sass, Georgette L. Pannuti, Antonio Lucchesi, John C.
Description	Author Affiliation: Sass GL ( Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA.);
Abstract	The male-specific lethal (MSL) complex of Drosophila is responsible for the presence of a monoacetylated isoform of histone H4 (H4Ac16), found exclusively on the X chromosome of males. This particular covalent modification of histone H4 is correlated with a 2-fold enhancement of the transcription of most X-linked genes in Drosophila males, which is the basis of dosage compensation in this organism. Although widespread along the X chromosome, the MSL complex is not distributed uniformly, as can be seen by the indirect cytoimmunofluorescence staining of larval salivary-gland polytene chromosomes. This distribution pattern has been interpreted as a reflection of the tissue-specific transcriptional activity of the larval salivary gland and as an indication that the MSL complex associates with active chromatin. We have tested this hypothesis by comparing the chromosomal distribution of the complex in two different tissues. We performed this comparison by following the pattern of association of the complex at a specific site on salivary-gland chromosomes during larval development and determining whether an ectopic promoter located in a complex-devoid region of the X chromosome is able to attract the complex upon activation. Our results indicate that, in contrast to other chromatin-remodeling complexes that enhance transcription, the MSL complex targets active chromatin.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chromatin Metabolism Dosage Compensation, Genetic Drosophila Proteins Physiology Drosophila Melanogaster Genetics Histones Nuclear Proteins Transcription, Genetic X Chromosome Acetylation Acetyltransferases Animals Binding Sites Chromosomal Proteins, Non-Histone DNA Helicases DNA-Binding Proteins Growth & Development Enhancer Elements, Genetic Histone Acetyltransferases Larva Macromolecular Substances Organ Specificity Ovary Ultrastructure Promoter Regions, Genetic Protein Binding Protein Processing, Post-Translational Salivary Glands Transcription Factors Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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