NDLI: The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants.

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The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Imamura, Osamu Campbell, Judith L.
Description	Author Affiliation: Imamura O ( Braun Laboratories 147-45, California Institute of Technology, Pasadena, CA 91125, USA.);
Abstract	Bloom syndrome is a disorder of profound and early cancer predisposition in which cells become hypermutable, exhibit high frequency of sister chromatid exchanges, and show increased micronuclei. BLM, the gene mutated in Bloom syndrome, has been cloned previously, and the BLM protein is a member of the RecQ family of DNA helicases. Many lines of evidence suggest that BLM is involved either directly in DNA replication or in surveillance during DNA replication, but its specific roles remain unknown. Here we show that hBLM can suppress both the temperature-sensitive growth defect and the DNA damage sensitivity of the yeast DNA replication mutant dna2-1. The dna2-1 mutant is defective in a helicase-nuclease that is required either to coordinate with the crucial Saccharomyces cerevisiae (sc) FEN1 nuclease in Okazaki fragment maturation or to compensate for scFEN1 when its activity is impaired. We show that human BLM interacts with both scDna2 and scFEN1 by using coimmunoprecipitation from yeast extracts, suggesting that human BLM participates in the same steps of DNA replication or repair as scFEN1 and scDna2.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenosine Triphosphatases Physiology Bloom Syndrome Enzymology DNA Helicases DNA Repair Exodeoxyribonucleases Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Deficiency Genetics Alkylating Agents Pharmacology DNA Replication DNA, Fungal Drug Effects Metabolism Enzyme Inhibitors Exodeoxyribonuclease V Genetic Complementation Test Hydroxyurea Methyl Methanesulfonate Protein Interaction Mapping RecQ Helicases Ribonucleotide Reductases Antagonists & Inhibitors Growth & Development Temperature Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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