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The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion.

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The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Joyce, Sebastian Wilson, Michael T. Olivares-villagómez, Danyvid Johansson, Cecilia Wang, Chyung-ru Wick, Mary Jo Van Kaer, Luc Singh, Avneesh K. Stanic, Aleksandar K.
Description	Author Affiliation: Wilson MT ( Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.);
Abstract	CD1d-restricted natural killer T (NKT) cells are a subset of regulatory T cells that react with glycolipid antigens. Although preclinical studies have effectively targeted NKT cells for immunotherapy, little is known regarding the early in vivo response of these cells to antigenic stimulation. We have analyzed the early response of NKT cells to glycolipid antigens and bacterial infection by using specific reagents for tracking these cells. Our results demonstrate dramatic in vivo expansion and surface phenotype alterations after NKT cell activation with alpha-galactosylceramide. In addition, we show significant NK1.1 down-modulation on NKT cells in the setting of oral Salmonella infection. Our results indicate that in vivo activation of NKT cells leads to a dynamic response characterized by surface receptor down-modulation and expansion. These findings alter current understanding of NKT cell biology and should aid in the rational design of NKT cell-based immunotherapies.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Down-Regulation Glycolipids Immunology Killer Cells, Natural Receptors, Antigen, T-Cell Animals Cells, Cultured Mice Mice, Inbred C57BL Polymerase Chain Reaction Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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