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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hammond, Kirsten J. L. Porcelli, Steven A. Sakai, Teruyuki Kronenberg, Mitchell Maltsev, Sergei D. Besra, Gurdyal S. Bénazet-sidobre, Lise Sidobre, Stéphane Ndonye, Rachel M. Richardson, Stewart K. Howell, Amy R. |
| Description | Author Affiliation: Sidobre S ( Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.); |
| Abstract | Natural killer (NK) T cells with an invariant Valpha14 rearrangement (Valpha14i) are the largest population of lipid antigen-specific T lymphocytes identified in animals. They react to the glycolipid alpha-galactosyl ceramide (alpha-GalCer) presented by CD1d, and they may have important regulatory functions. It was previously shown that the Valpha14i T cell antigen receptor (TCR) has a high affinity for the alpha-GalCer/CD1d complex, driven by a long half-life (t(1/2)). Although this result could have reflected the unique attributes of alpha-GalCer, using several related glycolipid compounds, we show here that the threshold for full activation of Valpha14i NKT cells by these glycosphingolipids requires a relatively high-affinity TCR interaction with a long t(1/2). Furthermore, our data are consistent with the view that the mechanism of recognition of these compounds presented by CD1d to the Valpha14i NKT cell TCR is likely to fit a lock-and-key model. Overall, these findings emphasize the distinct properties of glycosphingolipid antigen recognition by Valpha14i NKT cells. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 33 |
| Volume Number | 101 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2004-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Killer Cells, Natural Immunology Receptors, Antigen, T-Cell Metabolism T-Lymphocyte Subsets Animals Antigens Chemistry Antigens, CD1 Antigens, CD1d Binding Sites Cytokines Biosynthesis Glycosphingolipids In Vitro Techniques Kinetics Macromolecular Substances Mice Mice, Inbred C57BL Genetics Solubility Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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