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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Parsons, Simon Van Der Geer, Erwin P. L. Guichard, Sylvie Oswald, Iain D. H. Deeth, Robert J. Fernández, Rafael Fabbiani, Francesca P. A. Sadler, Peter J. Melchart, Michael Wang, Fuyi Lozano-casal, Patricia Habtemariam, Abraha Jodrell, Duncan I. Aird, Rhona |
| Description | Author Affiliation: Wang F ( School of Chemistry, University of Edinburgh, West Mains Road, EH9 3JJ Edinburgh, United Kingdom.); |
| Abstract | Organometallic compounds offer broad scope for the design of therapeutic agents, but this avenue has yet to be widely explored. A key concept in the design of anticancer complexes is optimization of chemical reactivity to allow facile attack on the target site (e.g., DNA) yet avoid attack on other sites associated with unwanted side effects. Here, we consider how this result can be achieved for monofunctional 'piano-stool' ruthenium(II) arene complexes of the type [(eta6-arene)Ru(ethylenediamine)(X)]n+. A potentially important activation mechanism for reactions with biomolecules is hydrolysis. Density functional calculations suggested that aquation (substitution of X by H2O) occurs by means of a concerted ligand interchange mechanism. We studied the kinetics and equilibria for hydrolysis of 21 complexes, containing, as X, halides and pseudohalides, pyridine (py) derivatives, and a thiolate, together with benzene (bz) or a substituted bz as arene, using UV-visible spectroscopy, HPLC, and electrospray MS. The x-ray structures of six complexes are reported. In general, complexes that hydrolyze either rapidly {e.g., X = halide [arene = hexamethylbenzene (hmb)]} or moderately slowly [e.g., X = azide, dichloropyridine (arene = hmb)] are active toward A2780 human ovarian cancer cells, whereas complexes that do not aquate (e.g., X = py) are inactive. An intriguing exception is the X = thiophenolate complex, which undergoes little hydrolysis and appears to be activated by a different mechanism. The ability to tune the chemical reactivity of this class of organometallic ruthenium arene compounds should be useful in optimizing their design as anticancer agents. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 51 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Organometallic Compounds Toxicity Ovarian Neoplasms Pathology Antineoplastic Agents Chemistry Cell Line, Tumor Cell Survival Drug Effects Drug Design Guanosine Monophosphate Metabolism Hydrolysis Inhibitory Concentration 50 Kinetics Ligands Molecular Structure Genetics Ruthenium Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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