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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zorat, Francesca Comar, Consuelo Nuti, Sandra Pozzato, Gabriele Abrignani, Sergio Barnaba, Vincenzo Rosa, Domenico De Gregorio, Ennio Saletti, Giulietta Houghton, Michael D'oro, Ugo |
| Description | Author Affiliation: Rosa D ( Chiron Vaccines, 53100 Siena, Italy.); |
| Abstract | Infection with hepatitis C virus (HCV), a leading cause of chronic liver diseases, can associate with B lymphocyte proliferative disorders, such as mixed cryoglobulinemia and non-Hodgkin lymphoma. The major envelope protein of HCV (HCV-E2) binds, with high affinity CD81, a tetraspanin expressed on several cell types. Here, we show that engagement of CD81 on human B cells by a combination of HCV-E2 and an anti-CD81 mAb triggers the JNK pathway and leads to the preferential proliferation of the naïve (CD27-) B cell subset. In parallel, we have found that B lymphocytes from the great majority of chronic hepatitis C patients are activated and that naïve cells display a higher level of activation markers than memory (CD27+) B lymphocytes. Moreover, eradication of HCV infection by IFN therapy is associated with normalization of the activation-markers expression. We propose that CD81-mediated activation of B cells in vitro recapitulates the effects of HCV binding to B cell CD81 in vivo and that polyclonal proliferation of naïve B lymphocytes is a key initiating factor for the development of the HCV-associated B lymphocyte disorders. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 51 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, CD Metabolism B-Lymphocytes Pathology Hepacivirus Physiology Hepatitis C Complications Lymphocyte Activation Lymphoma, B-Cell Antigens, CD81 Cell Proliferation Cells, Cultured Chronic Disease Enzyme Activation Gene Expression Regulation, Viral Immunology Virology JNK Mitogen-Activated Protein Kinases Receptors, CXCR3 Receptors, Chemokine Signal Transduction Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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