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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Papp, Kim Gilleaudeau, Patricia Carbonaro, Henrietta Abello, Maria Veronica Wittkowski, Knut M. Nussbaum, Rachel Fuentes-duculan, Judilyn Sullivan-whalen, Mary Lin, Shao-lee Garovoy, Marvin Novitskaya, Inna Kikuchi, Toyoko Lowes, Michelle A. Dummer, Wolfgang Cardinale, Irma Steinman, Ralph M. Chamian, Francesca Krueger, James G. |
| Description | Author Affiliation: Lowes MA ( Laboratory for Investigative Dermatology and Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA.); |
| Abstract | We find that CD11c(+) cells with many markers of dendritic cells (DCs) are a major cell type in the skin lesions of psoriasis. These CD11c(+) cells, which are evident in both epidermis and dermis, are the sites for the expression of two mediators of inflammation, inducible nitric oxide synthase (iNOS) and TNF-alpha in diseased skin. These cells express HLA-DR, CD40, and CD86, lack the Langerin and CD14 markers of Langerhans cells and monocytes, respectively, and to a significant extent express the DC maturation markers DC-LAMP and CD83. Treatment of psoriasis with efalizumab (anti-CD11a, Raptiva) strongly reduces infiltration by these DCs in patients responding to this agent. Disease activity after therapy was more related to DC infiltrates and iNOS mRNA levels than T cell infiltrates, and CD11c(+) cells responded more quickly to therapy than epidermal keratinocytes. Our results suggest that a type of DC, which resembles murine 'Tip-DCs' that can accumulate during infection, has proinflammatory effects in psoriasis through nitric oxide and TNF-alpha production, and can be an important target for suppressive therapies. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 52 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antibodies, Monoclonal Pharmacology Dendritic Cells Cytology Nitric Oxide Synthase Type II Physiology Psoriasis Pathology Tumor Necrosis Factor-alpha Antigens, CD Biosynthesis Antigens, CD11c Antigens, CD40 Antigens, CD86 Cell Separation Metabolism Flow Cytometry HLA-DR Antigens Immunoglobulins Immunohistochemistry Inflammation Lysosome-Associated Membrane Glycoproteins Membrane Glycoproteins Microscopy, Fluorescence RNA, Messenger Time Factors Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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