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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Simard, Frédéric White, Bradley J. Sharakhova, Maria V. Santolamazza, Federica Kayondo, Jonathan Della Torre, Alessandra Lobo, Neil F. Besansky, Nora J. Collins, Frank H. Sharakhov, Igor V. |
| Description | Author Affiliation: Sharakhov IV ( Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.); |
| Abstract | Paracentric chromosomal inversions are major architects of organismal evolution and have been associated with adaptations relevant to malaria transmission in anopheline mosquitoes. The processes responsible for their origin and maintenance, still poorly understood, can be illuminated by analysis of inversion breakpoint sequences. Here, we report the breakpoint structure of chromosomal inversion 2La from the principal malaria vector Anopheles gambiae and its relatives in the A. gambiae complex. The distal and proximal breakpoints of the standard (2L+a) arrangement contain gene duplications: full-length genes and their truncated copies at opposite ends. Intact genes without pseudogene copies in the alternative arrangement (2La) imply that 2L+a is derived and was viable despite damage to genes, because duplication preserved gene function. A unique origin for the interspecific 2La inversion was challenged previously by indirect genetic evidence, but breakpoint sequences determined from members of the A. gambiae complex strongly suggest their descent from a single event. The derived position of 2L+a, long considered ancestral in this medically important group, has significant implications for the phylogenetic history and the evolution of vectorial capacity in the A. gambiae complex. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 16 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Anopheles Gambiae Genetics Chromosome Breakage Chromosome Inversion Evolution, Molecular Insect Vectors Animals Chromosomes Genes Molecular Sequence Data Pseudogenes Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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