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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nicholls, Russell E. Conklin, Bruce R. Bailey, Christopher P. Kandel, Eric R. Zhang, Xiao-lei Stanton, Patric K. |
| Description | Author Affiliation: Nicholls RE ( Center for Neurobiology and Behavior, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA.); |
| Abstract | Presynaptic inhibitory G protein-coupled receptors play a critical role in regulating transmission at a number of synapses in the central and peripheral nervous system. We generated transgenic mice that express a constitutively active form of an inhibitory Galpha subunit to examine the molecular mechanisms underlying the actions of one such receptor, metabotropic glutamate receptor (mGluR) 2, at mossy fiber-CA3 synapses in the hippocampus. mGluR2 participates in at least three types of mossy fiber synaptic plasticity, (i) transient suppression of synaptic transmission, (ii) long-term depression (LTD), and (iii) inhibition of long-term potentiation (LTP), and we find that inhibitory Galpha signaling is sufficient to account for the actions of mGluR2 in each. The fact that constitutively active Galphai2 occludes the transient suppression of synaptic transmission by mGluR2, while enhancing LTD, suggests further that these two forms of plasticity are expressed via different mechanisms. In addition, the LTP deficit observed in constitutively active Galphai2-expressing mice suggests that mGluR2 activation may serve as a metaplastic switch to permit the induction of LTD by inhibiting LTP. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 16 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | GTP-Binding Protein Alpha Subunit, Gi2 Metabolism Long-Term Synaptic Depression Mossy Fibers, Hippocampal Receptors, Metabotropic Glutamate Synapses Synaptic Transmission Adenylyl Cyclase Inhibitors Animals Genetics Hippocampus Chemistry Mice Mice, Transgenic RNA, Messenger Agonists Antagonists & Inhibitors Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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