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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Altmann, Markus Sugden, Bill Wang, Jindong Hammerschmidt, Wolfgang Pich, Dagmar Ruiss, Romana |
| Description | Author Affiliation: Altmann M ( Department of Gene Vectors, GSF-National Research Center for Environment and Health, Marchioninistrasse 25, 81377 München, Germany.); |
| Abstract | EBV is a paradigm for human tumor viruses because, although it infects most people benignly, it also can cause a variety of cancers. Both in vivo and in vitro, EBV infects B lymphocytes in G0, induces them to become blasts, and can maintain their proliferation in cell culture or in vivo as tumors. How EBV succeeds in these contrasting cellular environments in expressing its genes that control the host has not been explained. We have genetically dissected the EBV nuclear antigen 1 (EBNA1) gene that is required for replication of the viral genome, to elucidate its possible role in the transcription of viral genes. Strikingly, EBNA1 is essential to drive transcription of EBV's transforming genes after infection of primary B lymphocytes. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 38 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Epstein-Barr Virus Nuclear Antigens Metabolism Gene Expression Regulation, Viral Herpesvirus 4, Human Genetics Transcription, Genetic Animals B-Lymphocytes Cytology Physiology Virology Cell Proliferation Cell Transformation, Neoplastic Genes, Reporter Phenotype Promoter Regions, Genetic Recombinant Fusion Proteins Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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