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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Oettgen, Herbert Knuth, Alexander Ayyoub, Maha Karbach, Julia Bender, Armin Ritter, Erika Jäger, Elke Pan, Linda Jäger, Dirk Hoffman, Eric Panicali, Dennis Gnjatic, Sacha Old, Lloyd J. Neumann, Antje Valmori, Danila Ritter, Gerd |
| Description | Author Affiliation: Jäger E ( Ludwig Institute Clinical Trial Center, Medizinische Klinik II, Hämatologie-Onkologie, Krankenhaus Nordwest, Steinbacher Hohl 2-26, 60488 Frankfurt, Germany. elke.jaeger@licr.org); |
| Abstract | NY-ESO-1 is a cancer/testis antigen expressed in a range of human malignancies, and a number of vaccine strategies targeting NY-ESO-1 are being developed. In the present study, the safety and immunogenicity of recombinant vaccinia-NY-ESO-1 and recombinant fowlpox-NY-ESO-1 were analyzed in a series of 36 patients with a range of different tumor types. Each construct was first tested individually at two different dose levels and then in a prime-boost setting with recombinant vaccinia-NY-ESO-1 followed by recombinant fowlpox-NY-ESO-1. The vaccines were well tolerated either individually or together. NY-ESO-1-specific antibody responses and/or specific CD8 and CD4 T cell responses directed against a broad range of NY-ESO-1 epitopes were induced by a course of at least four vaccinations at monthly intervals in a high proportion of patients. CD8 T cell clones derived from five vaccinated patients were shown to lyse NY-ESO-1-expressing melanoma target cells. In several patients with melanoma, there was a strong impression that the natural course of the disease was favorably influenced by vaccination. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 39 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antibody Formation Immunology Cancer Vaccines Immunity, Cellular Neoplasm Proteins Neoplasms Peptide Fragments Vaccines, Synthetic Antibodies Blood CD8-Positive T-Lymphocytes Adverse Effects Genetics Clone Cells Cohort Studies Cytotoxicity, Immunologic Epitopes Fowlpox Virus Metabolism Membrane Proteins Vaccination Vaccinia Virus Clinical Trial Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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