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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cunha, Isabela W. Lopes, Marilene H. Camargo, Anamaria A. Vibranovski, Maria D. Soares, Fernando A. Martins, Waleska K. Simpson, Andrew J. G. Bettoni, Fabiana De Souza, Sandro J. Parmigiani, Raphael B. |
| Description | Author Affiliation: Parmigiani RB ( Ludwig Institute for Cancer Research, SP 01509-010, São Paulo, Brazil.); |
| Abstract | Cancer/testis (CT) antigens are immunogenic proteins expressed in normal gametogenic tissues and in different types of tumors. CT antigens are promising candidates for cancer immunotherapy, and the identification of novel CT antigens is a prerequisite for the development of cancer vaccines. We have identified a CT antigen, named CTSP-1, with partial similarity to the breast differentiation antigen NY-BR-1. CTSP-1 presents several splicing and polyadenylation variants and has a very restricted expression pattern among normal tissues. CTSP-1 is exclusively expressed in normal testis and is aberrantly expressed in 47.6% (10 of 21) of tumor cell lines and in 44.4% (75 of 169) of tumors from different histological types. The highest percentages of positive expression were observed in melanomas (59.0%) followed by prostate (58.0%) and lung (57.0%) tumors. CTSP-1 is part of a highly conserved gene family, and members of this family also have a restricted expression pattern and similar protein structure. Antibodies against members of this gene family were detected in 10% (14 of 141) of plasma samples from patients with a wide spectrum of tumors. The highest percentages of antibody response were observed in patients with prostate (20.8%), thyroid (20.0%), and breast (16.6%) tumors. Because of its very restricted expression pattern in normal tissues and immunogenicity in different types of tumors, CTSP-1 should be considered a promising candidate for cancer immunotherapy. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 48 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, Neoplasm Genetics Immunology Neoplasms Nuclear Proteins Alternative Splicing Animals Classification Metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic Variation Mice Molecular Sequence Data Polyadenylation RNA, Messenger Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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