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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Opolon, Paule Mir, Lluis M. Corvol, Pierre Monnot, Catherine Germain, Stephane Le Jan, Sebastien Le Coz, Emmanuelle Philippe, Josette Connault, Elisabeth Galaup, Ariane Cazes, Aurelie Mekid, Halima |
| Description | Author Affiliation: Galaup A ( Institut National de la Santé et de la Recherche Médicale, Unit 36, 11 Place Marcelin Berthelot, 75005 Paris, France.); |
| Abstract | Angiopoietin-like 4 (ANGPTL4), a secreted protein of the angiopoietin-like family, is induced by hypoxia in both tumor and endothelial cells as well as in hypoxic perinecrotic areas of numerous cancers. Here, we investigated whether ANGPTL4 might affect tumor growth as well as metastasis. Metastatic 3LL cells were therefore xenografted into control mice and mice in which ANGPTL4 was expressed by using in vivo DNA electrotransfer. Whereas primary tumors grew at a similar rate in both groups, 3LL cells metastasized less efficiently to the lungs of mice that expressed ANGPTL4. Fewer 3LL emboli were observed in primary tumors, suggesting that intravasation of 3LL cells was inhibited by ANGPTL4. Furthermore, melanoma B16F0 cells injected into the retro-orbital sinus also metastasized less efficiently in mice expressing ANGPTL4. Although B16F0 cells were observed in lung vessels, they rarely invaded the parenchyma, suggesting that ANGPTL4 affects extravasation. In addition, recombinant B16F0 cells that overexpress ANGPTL4 were generated, showing a lower capacity for in vitro migration, invasion, and adhesion than control cells. Expression of ANGPTL4 induced reorganization of the actin cytoskeleton through inhibition of actin stress fiber formation and vinculin localization at focal contacts. Together, these results show that ANGPTL4, through its action on both vascular and tumor compartments, prevents the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 49 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Capillary Permeability Physiology Cell Movement Intercellular Signaling Peptides And Proteins Neoplasm Invasiveness Prevention & Control Neoplasm Metastasis Angiopoietins Animals Carcinoma, Lewis Lung Pathology Cell Line, Tumor Lung Neoplasms Lymph Nodes Lymphatic Metastasis Lymphopoiesis Melanoma, Experimental Mice Mice, Inbred C57BL Neovascularization, Physiologic Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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