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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bäckhed, Fredrik Crawford, Peter A. O'donnell, David Gordon, Jeffrey I. |
| Description | Author Affiliation: Bäckhed F ( Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA.); |
| Abstract | Lymphatic vessels develop from specialized venous endothelial cells. Using knockout mice, we found that fasting-induced adipose factor (Fiaf) is required for functional partitioning of postnatal intestinal lymphatic and blood vessels. In wild-type animals, levels of intestinal Fiaf expression rise during the first postnatal day and peak at day 2, which coincides with the onset of the lymphatico-venous partitioning abnormality in Fiaf-/- mutants on a mixed 129/SvJ:C57BL/6 genetic background. Fiaf deficiency is not associated with disruption of the blood vasculature or with lymphatic endothelial recruitment of smooth muscle cells. We identified Prox1, a critical regulator of lymphangiogenesis, as a downstream target for Fiaf signaling in the intestinal lymphatic endothelium. This organ-specific lymphovascular abnormality can be rescued by allowing embryonic Fiaf-/- intestinal isografts to develop in Fiaf+/+ recipients. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Blood Proteins Physiology Intestine, Small Blood Supply Growth & Development Lymphatic Vessels Anatomy & Histology Angiopoietins Animals Animals, Newborn Deficiency Genetics Genes, Homeobox Homeodomain Proteins Transplantation Lymphangiogenesis Mice Mice, Knockout Microcirculation Transplantation, Isogeneic Tumor Suppressor Proteins Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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