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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kallikourdis, Marinos Betz, Alexander G. Welch, Katie A. Andersen, Kristian G. |
| Description | Author Affiliation: Kallikourdis M ( Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, United Kingdom.); |
| Abstract | Regulatory T cells play an essential role in preventing fetal rejection by the maternal immune system. Here we show that, based on the expression of CCR5, regulatory T cells can be divided into a highly suppressive CCR5+ and a far less suppressive CCR5- subpopulation, suggesting that the former represent the effector arm of regulatory T cells. Although regulatory T cells from CCR5-/- gene deletion mutants still suppress, they are less effective mediators of maternal-fetal tolerance. The accumulation of CCR5+ regulatory T cells at this site appears to be enhanced by alloantigen. This finding is in stark contrast to the systemic expansion of regulatory T cells during pregnancy, which appears to be alloantigen-independent. The fact that CCR5+ regulatory T cells preferentially accumulate in the gravid uterus and that expression of CCR5 on regulatory T cells can be induced by activation lead us to propose that CCR5 is responsible for the accumulation of those regulatory T cells that have been activated by paternal antigens. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Isoantigens Metabolism Receptors, CCR5 T-Lymphocytes, Regulatory Immunology Uterus Animals Chemokine CCL4 Chemokines Genetics Chemokines, CC Gene Expression Immune Tolerance Lymphocyte Activation Maternal-Fetal Exchange Mice Mice, Inbred C57BL Mice, Knockout Models, Immunological Pregnancy RNA, Messenger Deficiency Cytology Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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