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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Butler, James S. Webb, Watt W. Chen, Huimin Rhoades, Elizabeth Loh, Stewart N. |
| Description | Author Affiliation: Chen H ( School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA.); |
| Abstract | The spectra of equilibrium chain conformation fluctuations of apomyoglobin (apoMb) as a function of folding, from the acid-denatured state at pH 2.6 through the stable molten globule state pH approximately 4.1 to the folded state at pH 6.3, are reported, as measured by fluorescence correlation spectroscopy. The conformational fluctuations, which are detected by quenching of an N-terminal fluorescent label by contact with various amino acids, can be represented by superpositions of decaying exponentials with time scales ranging from approximately 3 to approximately 200 micros. Both the time scales and amplitudes of the fluctuations increase with the degree of acid denaturation, with principal shifts associated with the transition across the molten globule state. Measurements of the diffusion of apoMb confirm theoretical values showing a approximately 40% increase in the hydrodynamic radius upon acid denaturation. This study uses the model protein apoMb to illustrate the complex scope of folding associated structural dynamics. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 25 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Apoproteins Chemistry Myoglobin Protein Conformation Protein Denaturation Protein Folding Spectrometry, Fluorescence Amino Acid Sequence Genetics Isolation & Purification Cloning, Molecular Diffusion Gene Expression Hydrogen-Ion Concentration Kinetics Models, Molecular Mutation Protein Structure, Secondary Time Factors Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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