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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Renner, Christian Zinth, Wolfgang Tavan, Paul Schrader, Tobias E. Babitzki, Galina Dong, Shou-liang Denschlag, Robert Löweneck, Markus Koller, Florian O. Moroder, Luis Cordes, Thorben Schreier, Wolfgang J. |
| Description | Author Affiliation: Schrader TE ( Munich Center for Integrated Protein Science, Ludwig-Maximilians-Universität München, Oettingenstrasse 67, 80538 Munich, Germany.); |
| Abstract | A light-switchable peptide is transformed with ultrashort pulses from a beta-hairpin to an unfolded hydrophobic cluster and vice versa. The structural changes are monitored by mid-IR probing. Instantaneous normal mode analysis with a Hamiltonian combining density functional theory with molecular mechanics is used to interpret the absorption transients. Illumination of the beta-hairpin state triggers an unfolding reaction that visits several intermediates and reaches the unfolded state within a few nanoseconds. In this unfolding reaction to the equilibrium hydrophobic cluster conformation, the system does not meet significant barriers on the free-energy surface. The reverse folding process takes much longer because it occurs on the time scale of 30 micros. The folded state has a defined structure, and its formation requires an extended search for the correct hydrogen-bond pattern of the beta-strand. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 40 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Protein Denaturation Protein Folding Amides Chemistry Magnetic Resonance Spectroscopy Models, Molecular Oxygen Peptides Metabolism Protein Conformation Protein Structure, Secondary Spectrophotometry, Infrared Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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