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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Marcucci, Guido Fernandez-cymering, Cecilia Morrison, Carl D. Chan, Kenneth K. Cimmino, Amelia Zanesi, Nicola Garzon, Ramiro Guler, Gulnur Callegari, Elisa Croce, Carlo M. Liu, Zhongfa Liu, Shujun Alder, Hansjuerg Fabbri, Muller Volinia, Stefano Huebner, Kay Costinean, Stefan Calin, George A. |
| Description | Author Affiliation: Fabbri M ( Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, and College of Pharmacy, Ohio State University, Columbus, OH 43210, USA.); |
| Abstract | MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles of miRNAs in carcinogenesis. We and others have shown that expression profiles of miRNAs are different in lung cancer vs. normal lung, although the significance of this aberrant expression is poorly understood. Among the reported down-regulated miRNAs in lung cancer, the miRNA (miR)-29 family (29a, 29b, and 29c) has intriguing complementarities to the 3'-UTRs of DNA methyltransferase (DNMT)3A and -3B (de novo methyltransferases), two key enzymes involved in DNA methylation, that are frequently up-regulated in lung cancer and associated with poor prognosis. We investigated whether miR-29s could target DNMT3A and -B and whether restoration of miR-29s could normalize aberrant patterns of methylation in non-small-cell lung cancer. Here we show that expression of miR-29s is inversely correlated to DNMT3A and -3B in lung cancer tissues, and that miR-29s directly target both DNMT3A and -3B. The enforced expression of miR-29s in lung cancer cell lines restores normal patterns of DNA methylation, induces reexpression of methylation-silenced tumor suppressor genes, such as FHIT and WWOX, and inhibits tumorigenicity in vitro and in vivo. These findings support a role of miR-29s in epigenetic normalization of NSCLC, providing a rationale for the development of miRNA-based strategies for the treatment of lung cancer. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 40 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carcinoma, Non-Small-Cell Lung Enzymology DNA (Cytosine-5-)-Methyltransferase Genetics DNA Methylation DNA, Neoplasm Lung Neoplasms MicroRNAs Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Lung Mortality Prognosis RNA, Neoplasm Survival Analysis Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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