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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vence, Luis Ito, Tomoki Liu, Yong-jun Ueno, Hideki Banchereau, Jacques Palucka, A. Karolina Fay, Joseph W. |
| Description | Author Affiliation: Vence L ( Baylor Institute for Immunology Research and Baylor Research Institute, Baylor University, Dallas, TX 75204, USA.); |
| Abstract | Although it is accepted that regulatory T cells (T regs) contribute to cancer progression, most studies in the field consider nonantigen-specific suppression. Here, we show the presence of tumor antigen-specific CD4(+) T regs in the blood of patients with metastatic melanoma. These CD4(+) T regs recognize a broad range of tumor antigens, including gp100 and TRP1 (melanoma tissue differentiation antigens), NY-ESO-1 (cancer/testis antigen) and survivin (inhibitor of apoptosis protein (IAP) family antigen). These tumor antigen-specific T regs proliferate in peripheral blood mononuclear cells (PBMC) cultures in response to specific 15-mer peptides, produce preferentially IL-10 and express high levels of FoxP3. They suppress autologous CD4(+)CD25(-) T cell responses in a cell contact-dependent manner and thus share properties of both naturally occurring regulatory T cells and type 1 regulatory T cells. Such tumor antigen-specific T regs were not detected in healthy individuals. These tumor antigen-specific T regs might thus represent another target for immunotherapy of metastatic melanoma. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 52 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, Neoplasm Blood Melanoma Pathology T-Lymphocytes, Regulatory Metabolism Biosynthesis CD4-Positive T-Lymphocytes Forkhead Transcription Factors Inhibitor Of Apoptosis Proteins Interleukin-10 Interleukin-2 Receptor Alpha Subunit Leukocytes, Mononuclear Membrane Glycoproteins Membrane Proteins Microtubule-Associated Proteins Neoplasm Metastasis Neoplasm Proteins Trypsin Trypsinogen Gp100 Melanoma Antigen Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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