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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hirabayashi, Yoshio Matsui, Takaaki Nabetani, Takuji Murata, Tomoko Kakinuma, Hisaya Okamoto, Hitoshi Thitamadee, Siripong Bessho, Yasumasa Hirate, Yoshikazu |
| Description | Author Affiliation: Matsui T ( Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Nara 630-0101, Japan. matsui@bs.naist.jp); |
| Abstract | The assembly of progenitor cells is a crucial step for organ formation during vertebrate development. Kupffer's vesicle (KV), a key organ required for the left-right asymmetric body plan in zebrafish, is generated from a cluster of ~20 dorsal forerunner cells (DFCs). Although several genes are known to be involved in KV formation, how DFC clustering is regulated and how cluster formation then contributes to KV formation remain unclear. Here we show that positive feedback regulation of FGF signaling by Canopy1 (Cnpy1) controls DFC clustering. Cnpy1 positively regulates FGF signals within DFCs, which in turn promote Cadherin1-mediated cell adhesion between adjacent DFCs to sustain cell cluster formation. When this FGF positive feedback loop is disrupted, the DFC cluster fails to form, eventually leading to KV malformation and defects in the establishment of laterality. Our results therefore uncover both a previously unidentified role of FGF signaling during vertebrate organogenesis and a regulatory mechanism underlying cell cluster formation, which is an indispensable step for formation of a functional KV and establishment of the left-right asymmetric body plan. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 24 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Fibroblast Growth Factor 8 Metabolism Nerve Tissue Proteins Signal Transduction Stem Cells Zebrafish Proteins Zebrafish Animals Animals, Genetically Modified Body Patterning Genetics Cadherins Cell Adhesion Embryo, Nonmammalian Cytology Embryology Feedback, Physiological Gene Expression Regulation, Developmental Green Fluorescent Proteins In Situ Hybridization Oligonucleotides, Antisense Organogenesis Receptor, Fibroblast Growth Factor, Type 1 Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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