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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tiewsiri, Kasorn Wang, Ping |
| Description | Author Affiliation: Tiewsiri K ( Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY 14456, USA.); |
| Abstract | The soil bacterium Bacillus thuringiensis (Bt) is the most successfully used biopesticide in agriculture, and its insecticidal protein genes are the primary transgenes used for insect control in transgenic crops. However, evolution of insect resistance to Bt toxins threatens the long-term future of Bt applications. To date, cases of resistance to Bt toxins have been reported in agricultural situations in six insect species, but the molecular basis for these cases of resistance remains unclear. Here we report that the resistance to the Bt toxin Cry1Ac in the cabbage looper, Trichoplusia ni, evolved in greenhouses, is associated with differential alteration of two midgut aminopeptidases N, APN1 and APN6, conferred by a trans-regulatory mechanism. Biochemical, proteomic, and molecular analyses showed that in the Cry1Ac-resistant T. ni, APN1 was significantly down-regulated, whereas APN6 was significantly up-regulated. The Cry1Ac resistance was correlated with down-regulation of APN1 but not with the up-regulation of APN6. The concurrent up-regulation of APN6 and down-regulation of APN1 might play a role in compensating for the loss of APN1 to minimize the fitness costs of the resistance. Along with identifying reduced expression of APN1 as the molecular basis of Bt resistance selected in an agricultural setting, our findings demonstrate the importance of APN1 to the mode of action of Bt toxin Cry1Ac. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 34 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, CD13 Metabolism Bacillus Thuringiensis Chemistry Bacterial Proteins Toxicity Brassica Parasitology Endotoxins Hemolysin Proteins Insecticide Resistance Drug Effects Moths Enzymology Animals Genetics Digestive System Electrophoresis, Polyacrylamide Gel Gene Expression Profiling Gene Expression Regulation, Enzymologic Genes, Insect Genetic Linkage Insect Proteins Larva Microvilli Molecular Sequence Data Molecular Weight Protein Binding Proteomics RNA, Messenger Transcription, Genetic Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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