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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Fujii-kuriyama, Yoshiaki Warner, Margaret Gustafsson, Jan-åke Butler, Ryan Suzuki, Hitoshi Inzunza, Jose |
| Description | Author Affiliation: Butler R ( Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204, USA.); |
| Abstract | The aryl hydrocarbon receptor (AhR) knockout mice raised in the laboratory of Fujii-Kuriyama have been under investigation for several years because of the presence in their urinary bladder of large, yellowish stones. The stones are composed of uric acid and become apparent in the bladders as tiny stones when mice are 10 wk of age. By the time the mice are 6 mo of age, there are usually two or three stones with diameters of 3-4 mm. The urate concentration in the serum was normal but in the urine the concentration was 40-50 mg/dL, which is 10 times higher than that in the WT littermates. There were no apparent histological pathologies in the kidney or joints and the levels of enzymes involved in elimination of purines were normal. The source of the uric acid was therefore judged to be from degradation of nucleic acids due to a high turnover of cells in the bladder itself. The bladder was fibrotic and the luminal side of the bladder epithelium was filled with eosinophilic granules. There was loss of E-cadherin between some epithelial cells, with an enlarged submucosal area filled with immune cells and sometimes invading epithelial cells. We hypothesize that in the absence of AhR there is loss of detoxifying enzymes, which leads to accumulation of unconjugated cytotoxins and carcinogens in the bladder. The presence of bladder toxins may have led to the increased apoptosis and inflammation as well as invasion of epithelial cells in the bladders of older mice. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Receptors, Aryl Hydrocarbon Genetics Uric Acid Urine Urinary Bladder Calculi Chemistry Pathology Urinary Bladder Cytology Animals Apoptosis Physiology Cadherins Deficiency Fibrosis Immunohistochemistry In Situ Nick-End Labeling Macrophages Metabolism Mice Mice, Inbred C57BL Mice, Knockout Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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