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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gómez-gaviro, María Victoria Matheu, Ander Booth, Sarah Lovell-badge, Robin Galichet, Christophe Scott, Charlotte E. Sesay, Abdul K. |
| Description | Author Affiliation: Gómez-Gaviro MV ( Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom. vgomez@recava.com); |
| Abstract | Neural stem cells (NSCs) reside in specialized niches in the adult mammalian brain, including the subventricular zone and the dentate gyrus, which act to control NSC behavior. Among other cell types within these niches, NSCs are found in close proximity to blood vessels. We carried out an analysis of the interaction between endothelial cells and NSCs, and show that betacellulin (BTC), a member of the EGF family and one of several signaling molecules made by the former, induces NSC proliferation and prevents spontaneous differentiation in culture. When infused into the lateral ventricle, BTC induces expansion of NSCs and neuroblasts, and promotes neurogenesis in the olfactory bulb and dentate gyrus, whereas specific blocking antibodies reduce the number of stem/progenitor cells. BTC-null mice are less able to regenerate neuroblast numbers compared with WT littermates following depletion of proliferating cells using cytosine-ß-d-arabinofuranoside. BTC acts via both the EGF receptor, located on NSCs, and ErbB4, located on neuroblasts, with the latter explaining why its effects are distinct from those of EGF itself. Our results suggest that BTC could be a good candidate to aid regenerative therapies. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Proliferation Endothelial Cells Metabolism Intercellular Signaling Peptides And Proteins Neural Stem Cells Physiology Neurogenesis Signal Transduction Animals Betacellulin Blotting, Western Cell Line Human Umbilical Vein Endothelial Cells Genetics Mice Microscopy, Confocal Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction Receptor, Epidermal Growth Factor Receptor, ErbB-4 Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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