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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schwaiger, Christine S. Börjesson, Sara I. Henrion, Ulrike Wallner, Björn Elinder, Fredrik Nelson, Erin M. Renhorn, Jakob Bjelkmar, Pär Lindahl, Erik |
| Description | Author Affiliation: Henrion U ( Division of Cell Biology, Department of Clinical and Experimental Medicine, Linköping University, SE-581 85 Linköping, Sweden.); |
| Abstract | Voltage-gated ion channels open and close in response to changes in membrane potential, thereby enabling electrical signaling in excitable cells. The voltage sensitivity is conferred through four voltage-sensor domains (VSDs) where positively charged residues in the fourth transmembrane segment (S4) sense the potential. While an open state is known from the Kv1.2/2.1 X-ray structure, the conformational changes underlying voltage sensing have not been resolved. We present 20 additional interactions in one open and four different closed conformations based on metal-ion bridges between all four segments of the VSD in the voltage-gated Shaker K channel. A subset of the experimental constraints was used to generate Rosetta models of the conformations that were subjected to molecular simulation and tested against the remaining constraints. This achieves a detailed model of intermediate conformations during VSD gating. The results provide molecular insight into the transition, suggesting that S4 slides at least 12 â « along its axis to open the channel with a 3(10) helix region present that moves in sequence in S4 in order to occupy the same position in space opposite F290 from open through the three first closed states. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 22 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Drosophila Proteins Metabolism Ion Channel Gating Physiology Shaker Superfamily Of Potassium Channels Animals Binding Sites Genetics Cadmium Chemistry Chelating Agents Pharmacology Computer Simulation Drosophila Melanogaster Egtazic Acid Kinetics Membrane Potentials Drug Effects Models, Molecular Mutation Oocytes Patch-Clamp Techniques Protein Binding Protein Structure, Tertiary Xenopus Laevis Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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