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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schild, Hansjörg Schütze, Kristian Probst, Hans Christian Muth, Sabine |
| Description | Author Affiliation: Muth S ( Institute for Immunology, University Medical Center of the Johannes Gutenberg University Mainz, D-55131 Mainz Germany.); |
| Abstract | Resting dendritic cells (DCs) induce tolerance of peripheral T cells that have escaped thymic negative selection and thus contribute significantly to protection against autoimmunity. We recently showed that CD4(+)Foxp3(+) regulatory T cells (Tregs) are important for maintaining the steady-state phenotype of DCs and their tolerizing capacity in vivo. We now provide evidence that DC activation in the absence of Tregs is a direct consequence of missing DC-Treg interactions rather than being secondary to generalized autoimmunity in Treg-less mice. We show that DCs that lack MHC class II and thus cannot make cognate interactions with CD4(+) T cells are completely unable to induce peripheral CD8(+) T-cell tolerance. Consequently, mice in which interactions between DC and CD4(+) T cells are not possible develop spontaneous and fatal cytotoxic T lymphocyte-mediated autoimmunity. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 23 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adaptive Immunity Immunology Autoimmunity Dendritic Cells Peripheral Tolerance T-Lymphocytes, Cytotoxic T-Lymphocytes, Regulatory Animals Body Weight Metabolism Flow Cytometry Genes, MHC Class II Genetics Histological Techniques Homeodomain Proteins Lymphocyte Activation Mice Mice, Transgenic Tamoxifen Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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