NDLI: Induction of IL-10 producing CD4+ T cells with regulatory activities by stimulation with IL-10 gene-modified bone marrow derived dendritic cells.

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Induction of IL-10 producing CD4+ T cells with regulatory activities by stimulation with IL-10 gene-modified bone marrow derived dendritic cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fu, C-L Chuang, Y-H Huang, H-Y Chiang, B-L
Description	Author Affiliation: Fu CL ( Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taiwan, ROC.)
Abstract	Dendritic cells (DCs) can induce both tolergenic as well as effective immune responses in the lung. Pulmonary DCs producing interleukin (IL)-10 mediated tolerance induced by respiratory exposure to antigen. IL-10 is an important immunosuppressive cytokine, which inhibits maturation and function of DC. To assess whether IL-10 producing DCs can exert the tolergenic effect through the differentiation of regulatory T cells, bone marrow derived DCs were genetically modified by IL-10 expressing adenovirus. IL-10 gene modified DCs (Ad-IL-10-DC) displayed a characteristic phenotype of immature DCs. Here we showed that in vitro repetitive stimulation of naïve DO11.10 CD4(+) T cells with Ad-IL-10-DCs resulted in a development of IL-10 producing T-cell regulatory cells. These T cells could not proliferate well but also lost their ability to produce interferon-gamma upon restimulation with irradiated splenocytes and ovalbumin peptide. Furthermore, in co-culture experiments these T cells inhibited the antigen-driven proliferation of naïve CD4+ T cells in a dose-dependent manner. Our findings demonstrated that IL-10 producing DCs had the potential to induce the differentiation of Tr1-like cells and suggested their therapeutic use.
File Format	HTM / HTML
ISSN	00099104
e-ISSN	13652249
DOI	10.1111/j.1365-2249.2008.03689.x
Journal	Clinical & Experimental Immunology
Issue Number	2
Volume Number	153
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-08-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Immunology Cd4-positive T-lymphocytes Immunology Dendritic Cells Interleukin-10 T-lymphocytes, Regulatory Adenoviridae Genetics Animals Bone Marrow Cells Cell Differentiation Coculture Techniques Genetic Vectors Pharmacology Immune Tolerance Interferon-gamma Lymphocyte Activation Mice Mice, Inbred Balb C Mice, Transgenic Transduction, Genetic Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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