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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lynch-day, Melinda A. Zhao, Mantong Xie, Zhiping Bartholomew, Clinton R. Du, Zhou Backues, Steven K. Umekawa, Midori Inoki, Ken Suzuki, Tsukasa Jin, Meiyan Klionsky, Daniel J. Kamath, Avani |
| Description | Author Affiliation: Bartholomew CR ( Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.); |
| Abstract | Autophagy has been implicated in a number of physiological processes important for human heath and disease. Autophagy involves the formation of a double-membrane cytosolic vesicle, an autophagosome. Central to the formation of the autophagosome is the ubiquitin-like protein autophagy-related (Atg)8 (microtubule-associated protein 1 light chain 3/LC3 in mammalian cells). Following autophagy induction, Atg8 shows the greatest change in expression of any of the proteins required for autophagy. The magnitude of autophagy is, in part, controlled by the amount of Atg8; thus, controlling Atg8 protein levels is one potential mechanism for modulating autophagy activity. We have identified a negative regulator of ATG8 transcription, Ume6, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels; deletion of any of these components leads to an increase in Atg8 and a concomitant increase in autophagic activity. A similar regulatory mechanism is present in mammalian cells, indicating that this process is highly conserved. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 28 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Autophagy Repressor Proteins Metabolism Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Gene Deletion HeLa Cells Histone Deacetylases Lysosomes Microtubule-Associated Proteins Models, Biological Models, Genetic Promoter Regions, Genetic Protein Kinases Signal Transduction Sin3 Histone Deacetylase And Corepressor Complex Transcription, Genetic Vacuoles Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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